Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice doi.org/10.26538/tjnpr/v5i11.14
Main Article Content
Abstract
Panax notoginseng has been used in Vietnamese traditional medicine to treat hemoptysis, nosebleeds, hemorrhage, menorrhagia after giving birth, stagnation, abdominal pain, and dysentery. This research aimed to evaluate and compare the antitumor effects of 70% ethanol extracts of Vietnamese P. notoginseng roots with steaming (PNS) and without steaming (PNO) on sarcoma 180–bearing mice. The evaluation of tumor suppression effects was based on assessment of tumor size, histopathology and survival time of tumor-bearing mice. The results showed that PNS at both doses of 300 and 900 mg/kg/day had good antitumor effects by reducing the volume of tumors and prolonging survival time of tumor-bearing mice compared to the group not taking drugs in a dose-dependent manner, equivalent to the positive agent of lentinan at 240 mg/kg/day. PNO also showed good antitumor activity, but it was still inferior to PNS. Hence, the 70% ethanol extracts from P. notoginseng roots both with and without steaming showed good antitumor effects.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Do TL. Vietnamese medicinal plants and remedies/substances. (12th Ed.). Ha Noi: Health Publishing House; 2004; 1294p.
Bui TTH, Tran TH, Nguyen TT, Do TH, Vu MH, Nguyen TH. Isolation of some saponins from the roots of Panax notoginseng grown in Vietnam before and after processing. J Med Mater. 2018; 23(1):3-10.
Qi H, Zhang Z, Liu J, Chen Z, Huang Q, Li J, Chen J, Wang M, Zhao D, Wang Z, Li X. Comparisons of Isolation Methods, Structural Features, and Bioactivities of the Polysaccharides from Three Common Panax Species: A Review of Recent Progress. Molecules. 2021; 26(16):4997.
Yang Y, Ju Z, Yang Y, Zhang Y, Yang L, Wang Z. Phytochemical analysis of Panax species: a review. J Ginseng Res. 2021; 45(1):1-21.
Liu H, Lu X, Hu Y, Fan X. Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy. Pharmacol Res. 2020; 161(06):105263.
Guo S, Xi X, Li J. Notoginsenoside R1: A systematic review of its pharmacological properties. Pharmazie. 2019; 74(11):641-647.
Xu C, Liu T, Liu H, Chen G, Guo Y. Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis. RSC Adv. 2019; 9(6):38558-38567.
Zhang C, Tong X, Qi B, Yu X, Dong S, Zhang S, Li X, Yu M. Components of Panax notoginseng saponins enhance the cytotoxicity of cisplatin via their effects on gap junctions. Mol Med Rep. 2013; 8(3):897-902.
Wang CZ, Xie JT, Zhang B, Ni M, Fishbein A, Aung HH, Mehendale SR, Du W, He TC, Yuan CS. Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. Int J Oncol. 2007;31(5):1149-1156.
Zhao H, Han Z, Li G, Zhang S, Luo Y. Therapeutic Potential and Cellular Mechanisms of Panax notoginseng on Prevention of Aging and Cell Senescence-Associated Diseases. Aging Dis. 2017; 8(6):721-739.
Wang CZ, Anderson S, Yuan CS. Phytochemistry and Anticancer Potential of Notoginseng. Am J Chin Med. 2016; 44(1):23-34.
Jia L, Zhao Y, Liang XJ. Current evaluation of the millennium phytomedicine-ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem. 2009; 16(22):2924-2942.
Park SC, Yoo HS, Park C, Cho CK, Kim GY, Kim WJ, Lee YW, Choi YH. Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. Int J Oncol. 2009; 35(1):121-127.
Xiong Y, Chen L, Man J, Hu Y, Cui X. Chemical and bioactive comparison of Panax notoginseng root and rhizome in raw and steamed forms. J Ginseng Res. 2019; 43(3):385-393.
Gu CZ, Qiao YJ, Wang D, Zhu HT, Yang CR, Xu M, Zhang YJ. New triterpenoid saponins from the steaming treated roots of Panax notoginseng. Nat Prod Res. 2018; 32(3):294-301.
He F, Ding Y, Liang C, Song S B, Dou DQ. Song GY, Kim YH. Antitumor effects of dammarane-type saponins from steamed Notoginseng. Pharmacogn Mag. 2014; 10(39):314-317.
Ha BTT, Ha TT, Thu NT, Ha DT, Hung VM, Hai NT. In vitro anti-cancer activity of some saponins isolated from Panax notoginseng grown in Northwest Vietnam before and after steaming. J Pract Med. 2020; 3(1128):37-40.
Kopper L, Van Hanh T, Lapis K. Experimental model for liver metastasis formation using Lewis lung tumor. J Cancer Res Clin Oncol. 1982; 103(1):31-38.
Bagley RG, Ren Y, Kurtzberg L, Weber W, Bangari D, Brondyk W, Teicher BA. Human choriocarcinomas: placental growth factor-dependent preclinical tumor models. Int J Oncol. 2012; 40(2):479-486.
Itokawa H, Ichihara Y, Watanabe K, Takeya K. An antitumor principle from Euphorbia lathyris. Planta Med. 1989; 55(3):271-272.
Geran RI, Greenberg NH, MacDonald MM, Schumacher A, Abbott BJ. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep. 1972; 3(2):1-103.
Ha BTT, Hung VM, Hai NT. Evaluation of acute and subchronic toxicity of NP(H) in experiment. J Military Pharmaco-med. 2021; 46(6):20-28.
Shin JW, Seol IC, Son CG. Interpretation of Animal Dose and Human Equivalent Dose for Drug Development. The J Korean Oriental Med. 2010; 31(3):1-7.
Zhang J, Zhou B, Jin S, Huang Z, Ma B, Shao Q, Zhu W. Mechanism of action of Panax notoginoside against lung cancer in mice based on response to CTSB gene. BMC Compl Med Ther. 2020; 20(1):367.
Kim TD, Thanh HN, Thuy DN, Duc LV, Thi TV, Manh HV, Boonsiri P, ThanhTB. Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam. Asian Pac J Trop Biomed. 2016; 6(9):795-800.
You S, Shi X, Yu D, Zhao D, An Q, Wang D, Zhang J, Li M, Wang C. Fermentation of Panax notoginseng root extract polysaccharides attenuates oxidative stress and promotes type I procollagen synthesis in human dermal fibroblast cells. BMC Complement Med Ther. 2021; 21(1):34.