Antitumor Effects of Ethanol Extract from Raw and Steaming Vietnamese Panax notoginseng Roots on Sarcoma 180 Tumor-Bearing Mice
doi.org/10.26538/tjnpr/v5i11.14
Keywords:
Panax notoginseng, steaming, antitumor, miceAbstract
Panax notoginseng has been used in Vietnamese traditional medicine to treat hemoptysis, nosebleeds, hemorrhage, menorrhagia after giving birth, stagnation, abdominal pain, and dysentery. This research aimed to evaluate and compare the antitumor effects of 70% ethanol extracts of Vietnamese P. notoginseng roots with steaming (PNS) and without steaming (PNO) on sarcoma 180–bearing mice. The evaluation of tumor suppression effects was based on assessment of tumor size, histopathology and survival time of tumor-bearing mice. The results showed that PNS at both doses of 300 and 900 mg/kg/day had good antitumor effects by reducing the volume of tumors and prolonging survival time of tumor-bearing mice compared to the group not taking drugs in a dose-dependent manner, equivalent to the positive agent of lentinan at 240 mg/kg/day. PNO also showed good antitumor activity, but it was still inferior to PNS. Hence, the 70% ethanol extracts from P. notoginseng roots both with and without steaming showed good antitumor effects.
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