Andrographolides as Antiviral Agents: Insights into Mechanisms, Modifications, and Delivery Innovations http://www.doi.org/10.26538/tjnpr/v7i12.1

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Published: Dec 31, 2023
Keywords:
viral infections, phytochemicals, antiviral activity, andrographolides, Andrographis paniculata

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Fredmoore L. Orosco
Virology and Vaccine Institute of the Philippines Program, Industrial Technology Development Institute, Department of Science and Technology, Bicutan, Taguig City, Philippines 1634
Jonathan E. Wong
Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czechia 37005

Abstract

Viral infection remains a pressing global health challenge, underscoring the need for novel antiviral interventions. Recently, the potential of andrographolides as potent antiviral agents against major viral infections has garnered substantial attention. This comprehensive review highlights their antiviral activities, focusing on their inhibitory mechanisms and their effects on viral replication. This article also examines their semi-synthetic modifications, novel delivery systems, pharmacokinetic properties, and safety profiles. This review encompasses a wide range of viral infections, including influenza, HIV, HBV, HSV, etc. Key findings revealed the ability of andrographolides to impede viral entry, replication, and release, offering promising avenues for therapeutic intervention. Semi-synthetic modifications enhance antiviral efficacy and broaden the spectrum of action. Innovative delivery systems such as microspheres, liposomes, niosomes, and nanoparticles enhance bioavailability and target-specific delivery. Despite these efforts, research gaps persist, emphasizing the need for clinical validation, optimal dosing, and thorough safety assessment. Interdisciplinary efforts in molecular biology, pharmaceutical innovation, and clinical investigations will shape the future landscape of andrographolides as potent antiviral agents, bolstering global efforts against viral infections.

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How to Cite
Orosco, F. L., & Wong, J. E. (2023). Andrographolides as Antiviral Agents: Insights into Mechanisms, Modifications, and Delivery Innovations: http://www.doi.org/10.26538/tjnpr/v7i12.1. Tropical Journal of Natural Product Research (TJNPR), 7(12), 5341-5354. https://tjnpr.org/index.php/home/article/view/3152
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Vol. 7 No. 12 (2023): Tropical Journal of Natural Product Research (TJNPR)
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biographies

Fredmoore L. Orosco, Virology and Vaccine Institute of the Philippines Program, Industrial Technology Development Institute, Department of Science and Technology, Bicutan, Taguig City, Philippines 1634

S&T Fellows Program, Department of Science and Technology, Bicutan, Taguig City, Philippines 1634

3Department of Biology, College of Arts and Sciences, University of the Philippines Manila, Ermita, Manila 1000

Jonathan E. Wong, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czechia 37005

Faculty of Science, University of South Bohemia in Ceske Budejovice, Czechia 37005

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