Antiacne and Antibacterial Bioactivity Properties of Teak (Tectona grandis) Flower Essential Oil http://www.doi.org/10.26538/tjnpr/v7i11.24

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Published: Dec 1, 2023
Keywords:
Essential oil, Antiacne, Antibacterial, GC-MS, Tectona grandis

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Diky S. Diningrat
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, 20221, Indonesia
Erly Marwani
The School of Life Sciences and Technology, Institut Teknologi Bandung, Bandung, 40132, Indonesia, Indonesia
Kusdianti
Department of Biology, Faculty of Mathematics and Natural Sciences Education, Universitas Pendidikan Indonesia, 40154, Indonesia.

Abstract

Acne is generally associated with Propionibacterium acnes, which is treated by administering anti-acne medication. The anti-acne drugs currently available are synthetic ingredients that cause side effects. The side effects of this synthetic anti-acne drug can be eliminated by chemicals derived from natural plants, such as those found in teak flower (Tectona grandis) essential oil. Therefore, this study aims to determine bioactive compounds' content and test teak essential oil's anti-acne activity. The steps taken in this research: The extraction of teak flower essential oil is made by steam distillation. The teak flower essential oil was then analyzed using a Gas Chromatography Mass Spectrophotometer (GC-MS). The results were evaluated using the MASLAB program and then analyzed using the PubChem NCBI database and PASS Online. The results of the GC-MS analysis showed that there were 47 bioactive compounds. The PubChem analysis results showed that 13 compounds had antibacterial activity. The antibacterial activity as an anti-acne agent of teak flower essential oil was assessed using the disc diffusion method according to the Bauer method. The results of the PASS Online analysis showed that the antibacterial mechanism, Protein synthesis inhibitor, membrane permeability inhibitor and cell wall synthesis inhibitor, with the highest Pa value of 0.804 in the compound Benzyl benzoate Benzoic acid, phenylmethyl ester (CAS) and the lowest Pa value was 1H-Benzimidazole, 2-(methylthio)-(CAS) 2-thiomethylbenzimidazole. Based on the results of the antibacterial activity test, it has strong activity against Propionibacterium acnes with an inhibition zone value of 23.1; 15; 15.4; 11.3 which has the potential as an anti-acne.

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Diningrat, D. S., Marwani, E., & Kusdianti. (2023). Antiacne and Antibacterial Bioactivity Properties of Teak (Tectona grandis) Flower Essential Oil: http://www.doi.org/10.26538/tjnpr/v7i11.24. Tropical Journal of Natural Product Research (TJNPR), 7(11), 5195-5202. https://tjnpr.org/index.php/home/article/view/3035
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Vol. 7 No. 11 (2023): Tropical Journal of Natural Product Research (TJNPR)
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Diningrat, D. S., Marwani, E., & Kusdianti. (2023). Antiacne and Antibacterial Bioactivity Properties of Teak (Tectona grandis) Flower Essential Oil: http://www.doi.org/10.26538/tjnpr/v7i11.24. Tropical Journal of Natural Product Research (TJNPR), 7(11), 5195-5202. https://tjnpr.org/index.php/home/article/view/3035

References

Daniele SG, Kim SR, Grada A, Moore AY, Suozzi KC, Bunick CG. Truncal acne and scarring: A comprehensive review of current medical and cosmetic approaches to treatment and patient management. Am. J. Clin. Dermatol. 2023; 24(2):199-223. https://doi.org/10.1007/s40257-022-00746-4

Melnik B, Chen W. Acne and Rosacea. Braun-Falco´s Dermatol. 2020;1-33. https://doi.org/10.1007/978-3-662-58713-3_71-1

Bhatnagar A, Mitra D, Kishore K, Kumar M, Valarmathi T, Kumar A, Kumar R. Efficacy of carbon peel laser in acne vulgaris in skin of color: A single center prospective study. J. Cutaneous and Aesthetic Surg. 2023; 23:1-5. https://doi.org/10.4103/JCAS.JCAS_141_22

Eichenfield DZ, Sprague J, Eichenfield LF. Management of acne vulgaris: a review. Jama. 2021; 326(20):2055-67. https://doi.org/10.1001/jama.2021.17633

Mendes-Bastos P, Ladizinski B, Guttman-Yassky E, Jiang P, Liu J, Prajapati VH, Simpson EL, Vigna N, Teixeira HD, Barbarot S. Characterization of acne associated with upadacitinib treatment in patients with moderate-to-severe atopic dermatitis: a post hoc integrated analysis of 3 phase 3 randomized, double-blind, placebo-controlled trials. J. Am. Acad. Dermatol. 2022; 87(4):784-91. https://doi.org/10.1016/j.jaad.2022.06.012

Tamara A, Anggowarsito JL, Tandyono V. Association between magnesium levels and the severity of Acne vulgaris. J. Widya Medika Junior. 2021; 3(4):237-41. https://doi.org/10.33508/jwmj.v3i4.3504

Bhate K, Lin LY, Barbieri JS, Leyrat C, Hopkins S, Stabler R, Shallcross L, Smeeth L, Francis N, Mathur R, Langan SM. Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review. BJGP open. 2021; 5(3):1-5. https://doi.org/10.3399/BJGPO.2020.0181

Martins AM, Marto JM, Johnson JL, Graber EM. A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea. Antibiotics. 2021; 10(7):757-61. https://doi.org/10.3390/antibiotics10070757

Otlewska A, Baran W, Batycka-Baran A. Adverse events related to topical drug treatments for acne vulgaris. Expert Opin. Drug Saf. 2020; 19(4):513-21. https://doi.org/10.1080/14740338.2020.1757646

Diningrat DS, Widiyanto SM, Pancoro A, Shim D, Panchangam B, Zembower N, Carlson JE. Transcriptome of teak (Tectona grandis, Lf) in vegetative to generative stages development. J. Plant Sci. 2015; 10(1):1-5. https://doi.org/10.3923/jps.2015.1.14

Diningrat DS, Widiyanto SM, Pancoro A, Shim D, Panchangam B, Zembower N, Carlson JE. Identification of Terminal Flowering1 (TFL1) Genes Associated with the Teak (Tectona grandis) Floral Development Regulation Using RNA-seq. Res. J. Bot. 2015; 10(1):1-5. https://doi.org/10.3923/rjb.2015.1.13

Islam AM, Suttiyut T, Anwar MP, Juraimi AS, Kato-Noguchi H. Allelopathic properties of Lamiaceae species: Prospects and challenges to use in agriculture. Plants. 2022; 11(11):1-45. https://doi.org/10.3390/plants11111478

Sandhya S, Mehta S, Pandey S, Husen A. Adventitious root formation in cuttings as influenced by genotypes, leaf area, and types of cuttings. In Environmental, Physiological and Chemical Controls of Adventitious Rooting in Cuttings. Acad. Press. 2022; 381-395. https://doi.org/10.1016/B978-0-323-90636-4.00021-0

Asdaq SM, Nayeem N, Alam MT, Alaqel SI, Imran M, Hassan EW, Rabbani SI. Tectona grandis Lf: A comprehensive review on its patents, chemical constituents, and biological activities. Saudi J. Biol. Sci. 2022; 29(3):1456-64. https://doi.org/10.1016/j.sjbs.2021.11.026

Sousa VI, Parente JF, Marques JF, Forte MA, Tavares CJ. Microencapsulation of essential oils: A review. Polym. 2022; 14(9):1730-41. https://doi.org/10.3390/polym14091730

Diningrat DS, Sari AN, Harahap NS. Potential of Hanjeli (Coix lacryma-jobi) essential oil in preventing SARS-CoV-2 infection via blocking the Angiotensin Converting Enzyme 2 (ACE2) receptor. J. Plant Biotechnol. 2021; 48(4):289-303. https://doi.org/10.5010/JPB.2021.48.4.289

Diningrat DS, Sari AN, Harahap NS. In silico study of the toxicity and antiviral activity prediction of jamblang (Syzygium cumini) leaves essential oil as ACE2 inhibitor. Pharmacologyonline. 2021; 3:1334-51. https://pharmacologyonline.silae.it/front/archives_2021_3

Wasilah S, Sari AN, Nasution RS, Diningrat DS. Anti-meningitis agent potentially of Syzigium cumini Essential oil by GC-MS. In IOP Conference Series: Earth and Enviro. Sci. 2021; 753(1):012051-55). IOP Publishing. https://doi.org/10.1088/1755-1315/753/1/012051

Bhavaniramya S, Vishnupriya S, Vijayarani K, Vanajothi R. Elucidating the Role of Essential Oils in Pharmaceutical and Industrial Applications. Essential Oils: Extr. Methods Appl. 2023; 14:185-205. https://doi.org/10.1002/9781119829614.ch9

Filimonov DA, Lagunin AA, Gloriozova TA, Rudik AV, Druzhilovskii DS, Pogodin PV, Poroikov VV. Prediction of the biological activity spectra of organic compounds using the PASS online web resource. Chem. Heterocycl. Compd. 2014; 50:444-57. https://doi.org/10.3390/ijms21207492

Suresh A, Velusamy S, Ayyasamy S, Rathinasamy M. Techniques for essential oil extraction from kaffir lime and its application in health care products—A review. Flavour Fragance J. 2021; 36(1):5-21. https://doi.org/10.1002/ffj.3626

Hariyadi MA, Yahya S, Wachjar A. Agro-morphologies and physicochemical properties of flower bud, stem and leaf oils in two clove varieties (Syzygium aromaticum L. Merr. and Perry.) originated from Ambon island. Chiang Mai Univ. J. Nat. Sci. 2020; 19(3):516-30. https://www.thaiscience.info/Journals/Article/CMUJ/10991134.pdf

Robiatun RR, Pangondian A, Paramitha R, Rani Z, Gultom ED. Formulation and evaluation of hand sanitizer gel from clove flower extract (Eugenia aromatica L.). Int. J. Sci. Technol. Manage. 2022; 3(2):484-91. https://doi.org/10.46729/ijstm.v3i2.472

Mehalaine S, Chenchouni H. Quantifying how climatic factors influence essential oil yield in wild-growing plants. Arabian J. Geosci. 2021; 14(13):1257. https://doi.org/10.1007/s12517-021-07582-6

AL-Hmadi H, El Mokni R, Joshi RK, Ashour ML, Hammami S. The impact of geographical location on the chemical compositions of Pimpinella lutea Desf. growing in Tunisia. Appl. Sci. 2021; 11(16):7739-51. https://doi.org/10.3390/app11167739

Shehata SA, Abdeldaym EA, Ali MR, Mohamed RM, Bob RI, Abdelgawad KF. Effect of some citrus essential oils on post-harvest shelf life and physicochemical quality of strawberries during cold storage. Agron. 2020; 10(10):1466-75. https://doi.org/10.3390/agronomy10101466

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L. PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res. 2021; 49(D1): D1388-95. https://doi.org/10.1093/nar/gkaa971

Yan J, Liu W, Cai J, Wang Y, Li D, Hua H, Cao H. Advances in phenazines over the past decade: Review of their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies. Mar. Drugs. 2021; 19(11):610. https://doi.org/10.3390/md19110610

Lobiuc A, Pavăl NE, Mangalagiu II, Gheorghiță R, Teliban GC, Amăriucăi-Mantu D, Stoleru V. Future antimicrobials: Natural and functionalized phenolics. Mol. 2023; 28(3):1114-21. https://doi.org/10.3390/molecules28031114

Guimarães AC, Meireles LM, Lemos MF, Guimarães MC, Endringer DC, Fronza M, Scherer R. Antibacterial activity of terpenes and terpenoids present in essential oils. Mol. 2019; 24(13):2471-82. https://doi.org/10.3390/molecules24132471

Ibtisam AA. Inhibitory Activity of Anti-Acne Serum Ethanol Extract from Natural Materials: A Literature Review. Manganite J. Chem. Educ. 2022; 1(1):21-7. https://jurnal.institutsunandoe.ac.id/index.php/manganite/article/view/75

Ardhany SD, Fansuri MA, Novaryatiin S. Pharmacognostic Study of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) and its Clay Mask Against Acne-Causing Bacteria. Trop. J. Nat. Prod. Res. 2022; 6(10):1614-1621. http://www.doi.org/10.26538/tjnpr/v6i10.9

Ratnah S, Salasa AM, Ramadhan DS. Formulation, Physical Quality, and Microbial Contamination Tests of Anti-Acne Cream from Longan (Euphoria longan [Lour. Steud.]) Seed Extract. Trop. J. Nat. Prod. Res. 2023; 7(7):3297-3305. http://www.doi.org/10.26538/tjnpr/v7i7.5

Khamphukdee C, Chulikhit Y, Monthakantirat O, Maneenet J, Boonyarat C, Daodee S. Phytochemical Constituents and Antioxidative Activity of Schleichera oleosa Fruit: Trop. J. Nat. Prod. Res. 2021; 5(8):1445-9. http://www.doi.org//10.26538/tjnpr/v5i8. 20.