Chemical Composition and Biological Activities of Essential Oil from <i>Plectranthus amboinicus</i> Collected in Dak Lak, Vietnam

http://www.doi.org/10.26538/tjnpr/v7i11.25

Authors

  • Dam T. B. Hanh Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000 Vietnam
  • Truong N. Ngu Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000 Vietnam
  • Phan H. T. Bao Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000 Vietnam
  • Nguyen P. D. Nguyen Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000 Vietnam
  • Phan V. Trong Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000 Vietnam
  • Le T. T. Loan Tay Nguyen University, Buon Ma Thuot, Dak Lak 630000 Vietnam
  • Do T. Lam Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay District, Hanoi 122100, Vietnam
  • Phi H. Nguyen Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay District, Hanoi 122100, Vietnam
  • Pham T. H. Khuyen chool of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son District, Danang City 550000, Vietnam
  • Phu C. H. Truong School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son District, Danang City 550000, Vietnam
  • Manh H. Tran School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son District, Danang City 550000, Vietnam
  • Vu D. Giap HaUI Institute of Technology, Hanoi University of Industry (HaUI), 298 Cau Dien, Bac Tu Liem, Hanoi 10000, Vietnam
  • Dao C. To Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam

Keywords:

antioxidant, antimicrobial, caryophyllene, carvacrol, amboinicus, Plectranthus

Abstract

Plectranthus amboinicus (Lamiaceae) is a medicinal plant widely cultivated and naturalized in the tropics of the Old and New World, with a history of use in folk medicine. However, there has been no prior investigation into the chemical composition and biological properties of this species in the Dak Lak Province, Vietnam. In this study, the essential oil extracted from P. amboinicus, collected in Buon Ma Thuot City in Dak Lak Provincfe was analyzed using gas chromatography-mass spectrometry (GC-MS). A total of 89 compounds were identified, constituting 0.62% of the oil; the major constituents included 2,3,5,6-tetramethylphenol (67.94%), caryophyllene (9.74%), trans-α-bergamotene (5.82%), α-humulene (3.20%), γ-terpinene (2.5%), o-cymene (1.90%), and terpinen-4-ol (1.14%). Notably, the carvacrol content exceeded previously reported values. In addition, P. amboinicus showed strong antibacterial activity against Escherichia coli using the agar disc diffusion method, with approximately 88.35% inhibition and a diameter of 47.3 mm. The antioxidant capacity of the essential oil was evaluated with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, yielding an antioxidant efficiency of 89.21% and an IC50 value of 44.15 μg/mL. This demonstrates the high pharmaceutical potential of the P. amboinicus species grown in Vietnam.

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Published

2023-12-01

How to Cite

Hanh, D. T. B., Ngu, T. N., Bao, P. H. T., Nguyen, N. P. D., Trong, P. V., Loan, L. T. T., … To, D. C. (2023). Chemical Composition and Biological Activities of Essential Oil from <i>Plectranthus amboinicus</i> Collected in Dak Lak, Vietnam: http://www.doi.org/10.26538/tjnpr/v7i11.25. Tropical Journal of Natural Product Research (TJNPR), 7(11), 5203–5210. Retrieved from https://tjnpr.org/index.php/home/article/view/3028

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