The <i>In Vivo</i> Anti-Inflammatory Effects of Qt-2 (A Traditional Medicine Remedy) Water Extract http://www.doi.org/10.26538/tjnpr/v7i11.21

Main Article Content

Tuan T. Vo
Tuan A. Phan
Thuy T. Lam
Nguyet T. Tran
Hoang M. Le

Abstract

This study investigated the in vivo anti-inflammatory effect of QT-2, a traditional medicinal remedy renowned for its potential in treating arthritis. We assessed its acute and chronic anti-inflammatory properties at two different doses (11.8 g/kg/day and 23.6 g/kg/day) using three in vivo models. The results revealed significant anti-inflammatory effects in the first carrageenan-induced paw edema model. QT-2 extract demonstrated a discernible reduction in paw edema volume, statistically comparable to the diclofenac 15 mg/kg treated group. In the second peritonitis model, both doses of QT-2 extract exhibited pronounced anti-inflammatory potential, leading to significant reductions in transudate volume, protein concentration within the transudate, and lowered optical density, comparable to the diclofenac 15 mg/kg treated group. In the third anti-granuloma model, both QT-2 extract doses caused marked reductions in the weight of dried and fresh granulomas, equivalent to the Prednisolone 15 mg/kg treated group. These results demonstrate the anti-inflammatory capability of QT-2 for inflammatory-related conditions.

Article Details

How to Cite
Vo, T. T., Phan, T. A., Lam, T. T., Tran, N. T., & Le, H. M. (2023). The <i>In Vivo</i> Anti-Inflammatory Effects of Qt-2 (A Traditional Medicine Remedy) Water Extract: http://www.doi.org/10.26538/tjnpr/v7i11.21. Tropical Journal of Natural Product Research (TJNPR), 7(11), 5178–5182. Retrieved from https://tjnpr.org/index.php/home/article/view/3026
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Articles
Author Biography

Tuan A. Phan, Department of Traditional Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam 

Ha Noi college of Pharmacy, Ha Noi, Vietnam

References

Poudel P, Goyal A, Lappin SL. Inflammatory Arthritis. Treasure Island (FL): StatPearls; 2023.

Pisetsky DS, Ward MM: Advances in the treatment of inflammatory arthritis. Best Pract Res Clin Rheumatol 2012; 26:251–61.

Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C: The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int 2021; 41:863–77.

World Health Organization. Rheumatoid arthritis. [online] 2023. [cited 2023 Sep 1]. Available from: https://www.who.int/news-room/fact-sheets/detail/rheumatoid-arthritis.

Bullock J, Rizvi SAA, Saleh AM, Ahmed SS, Do DP, Ansari RA, Ahmed J: Rheumatoid Arthritis: A Brief Overview of the Treatment. Med Princ Pract 2019; 27:501–7.

Zhang E: Bi Syndrome (Arthralgia Syndrome). J Tradit Chin Med 2010; 30:145–52

Liu Z. Essentials of Chinese Medicine. London: Springer; 2010.

Defang L, Jiao Y, Mingdong Y, Ming Y, Yong L, Jun Z, Mingyang G, Mei Y, Weili Y, Wei Z, Hua L, Yonghe H: Effect of Sanhuangyilong decoction plus methotrexate on tumor necrosis factor-alpha and interferon-gamma in serum and synovial fluid in rheumatoid arthritis patients with symptom pattern of damp heat obstruction. J Tradit Chin Med 2016; 36:625–33.

Yang M, Guo M-Y, Luo Y, Yun M-D, Yan J, Liu T, Xiao C-H: Effect of Artemisia annua extract on treating active rheumatoid arthritis: A randomized controlled trial. Chin J Integr Med 2017; 23:496–503.

Ouyang G, Feng X, Xiao L, Huang Z, Xia Q, Zhu F: Effects of Chinese herbal medicine Qianggu Capsule on patients with rheumatoid arthritis-induced osteoporosis: a report of 82 cases. Zhong Xi Yi Jie He Xue Bao 2012; 10:1394–9.

Cameron M, Gagnier JJ, Chrubasik S: Herbal therapy for treating rheumatoid arthritis. Cochrane Database Syst Rev 2011:CD002948 doi:10.1002/14651858.CD002948.pub2.

Nguyen PH, Tran VD, Pham DT, Dao TNP, Dewey RS: Use of and attitudes towards herbal medicine during the COVID-19 pandemic: A cross-sectional study in Vietnam. Eur J Integr Med. 2021; 44:101328.

kDôTât́Li, Nguyên Xuân Duñg: Native drugs of Vietnam: which traditional and scientific approaches? J Ethnopharmacol 1991; 32:51–6

.

Dung TN, Bodeker G: Tue Tinh: founder of Vietnamese traditional medicine. J Altern Complement Med 2001; 7:401–3.

Vo TT, Lam TT, Phan TA, Le HM: Evaluation of Analgesic Effects of Herbal Formula Qt-2 on Experimental Mice Model. Trop J Nat Prod Res. 2023; 7:3671–5.

Le HM, Huynh NTK, Vo TT, Nguyen TTB, Nguyen QM: Evaluation of Pain-Relieving Effect of The Herbal Remedy “Hoang Ky Que Chi Ngu Vat Thang” in Animal Model. Trop J Nat Prod Res. 2023; 7:3153–7.

Ca W, Ea R, Gw N: Carrageenan-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962; 111.

Clementi G, Caruso A, Cutuli VM, Prato A, Mangano NG, Amico-Roxas M: Anti-inflammatory activity of adrenomedullin in the acetic acid peritonitis in rats. Life Sci 1999; 65:PL203-208

Meshram GG, Kumar A, Rizvi W, Tripathi CD, Khan RA: Evaluation of the anti-inflammatory activity of the aqueous and ethanolic extracts of the leaves of Albizzia lebbeck in rats. J Tradit Complement Med 2016; 6:172–5.

Di Rosa M, Sorrentino L: The mechanism of the inflammatory effect of carrageenan. Eur J Pharmacol 1968; 4:340–2.

Fu X-Q, Cai J-Y, Huang Q-Y, Li D-J, Li N, Li M-J: Prednisone may induce immunologic tolerance by activating the functions of decidual immune cells in early pregnancy. Oncotarget 2017; 8:102191–8.

Bisht D, Rashid M, Arya RKK, Kumar D, Chaudhary SK, Rana VS, Sethiya NK: Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight. Phytomed Plus 2022; 2:100206.

Jia W, He X, Jin W, Gu J, Yu S, He J, Yi Z, Cai B, Gao H, Yang L: Ramulus Cinnamomi essential oil exerts an anti-inflammatory effect on RAW264.7 cells through N-acylethanolamine acid amidase inhibition. J Ethnopharmacol 2023; 317:116747.

Gao J, Yang X, Yin W: From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae. Evid Based Complement Alternat Med 2016; 2016:3898957.

Li J, Huang H-Y, Lin Y-C-D, Zuo H, Tang Y, Huang H-D: Cinnamomi ramulus inhibits cancer cells growth by inducing G2/M arrest. Front Pharmacol 2023; 14.

Liu J, Zhang Q, Li R-L, Wei S-J, Huang C-Y, Gao Y-X, Pu X-F: The traditional uses, phytochemistry, pharmacology and toxicology of Cinnamomi ramulus: a review. J Pharm Pharmacol 2020; 72:319–42.

Lee S-J, Park S-S, Kim W-J, Moon S-K: Gleditsia sinensis thorn extract inhibits proliferation and TNF-α-induced MMP-9 expression in vascular smooth muscle cells. Am J Chin Med 2012; 40:373–86.

Leite C dos S, Bonafé GA, Carvalho Santos J, Martinez CAR, Ortega MM, Ribeiro ML: The Anti-inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders. Int J Mol Sci 2022; 23:4121.

Yin G, Cao L, Xu P, Jeney G, Nakao M, Lu C: Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl(4))-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol Biochem 2011; 37:209–16.

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L: Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 2017; 9:7204–18.