A Single-Blind, Randomized, Controlled Trial Assessing the Efficacy and Safety Parameters of Traditional Thai Medicine, Aphayathikun, in Prediabetic Men with Lower Urinary Tract Symptoms



  • Teerawat Sudkhaw Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand
  • Junya Saejan Yala Regional Hospital, 152 Siroros Rd, Tambon Sateng, Mueang Yala District, Yala 95000
  • Chananan Suppala Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand
  • Sineenart Sanpinit School of Medicine, Walailak University, 222 Thaiburi, Thasala District, Nakhon Si Thammarat 80160 Thailand
  • Palika Wetchakul School of Medicine, Walailak University, 222 Thaiburi, Thasala District, Nakhon Si Thammarat 80160 Thailand
  • Sasitorn Chusri Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand


Traditional Thai Medicine, Lower urinary tract symptoms, Prediabetes, Aphayathikun


Lower urinary tract symptoms (LUTS) are not only more common in the elderly, but various pathophysiological pathways suggest a link between hyperglycemia and LUTS. Due to the long-standing traditional use of medicinal plants in Thailand, the present work aims to establish the safety and efficacy of Aphayathikun (AP), a recorded Thai Traditional medicinal drug for LUTS. The standardized decoction of AP has been established, and phenolic and flavonoid content, antioxidant activity, and in vivo toxicity were assessed using previously published methods. A randomized, open-label, controlled study was conducted on 34 prediabetic men with mild to moderate uncomplicated LUTS. As a supplementary treatment for standard self-management, 30 mL of AP decoction was administered thrice daily before meals for 14 consecutive days. Baseline and endpoint (the 4th week) improvements in IPSS scores, blood glucose control, serum lipid profiles, and liver function testing of the subjects were determined. There was an improvement in the total IPSS score and a significant decrease in the IPSS voiding and storage subscores among the subjects in the AP group. Additionally, the quality-of-life index, as measured by the IPSS, and the number of nocturia episodes per night decreased significantly from baseline to the 4th week in the AP group. This traditional polyherbal preparation, AP decoction, appears to be a safe and effective therapy option for the alternative treatment of mild-to-moderate LUTS in prediabetic patients.

Author Biography

Sasitorn Chusri, Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand

School of Health Science and Biomedical Technology Research Group for Vulnerable, Mae Fah Luang University, Thasud, Muang, Chiang Rai, 57100 Thailand


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How to Cite

Sudkhaw, T., Saejan, J., Suppala, C., Sanpinit, S., Wetchakul, P., & Chusri, S. (2023). A Single-Blind, Randomized, Controlled Trial Assessing the Efficacy and Safety Parameters of Traditional Thai Medicine, Aphayathikun, in Prediabetic Men with Lower Urinary Tract Symptoms: http://www.doi.org/10.26538/tjnpr/v7i11.12. Tropical Journal of Natural Product Research (TJNPR), 7(11), 5097–5105. Retrieved from https://tjnpr.org/index.php/home/article/view/3019

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