Subacute Toxicity Test of Ethanol Extract of Sungkai Leaf (Peronema Canescens Jack.) on Sgot and Sgpt Levels http://www.doi.org/10.26538/tjnpr/v7i11.5

Abstract

Sungkai plant (Peronema canescens Jack.) is an herbal plant that people widely use traditionally to treat various diseases. Sungkai is proven to have immunostimulant, antihyperuricemia, and antibacterial activities. Due to its widespread use and to ensure its safety, it is necessary to evaluate its toxicity. This study aimed to determine the effect of variations in dose and duration of administration of ethanol extract of Sungkai leaves (Peronema canescens Jack.) on SGPT and SGOT levels in male white mice. Thirty-six mice divided into four groups (a control group and three treatment groups) of nine each were used for this study. The control group received 0.5% Na CMC suspension, and the treatment groups (II-IV) were given the ethanol extract suspension of Sungkai leaves (Peronema canescens Jack.) at a dose of 200, 400 and 800 mg/kg BW p.o, respectively. The extracts were administered daily to the experimental animals for 7, 14, and 21 days. SGPT and SGOT levels were examined on days 8, 15 and 22 using a 5010 v5+ photometer. Data analysis was performed using the SPPS with a two-way ANOVA test based on variations in dose and duration of administration. The results of this study indicate that the ethanol extract of Sungkai leaves has no significant effect on SGPT and SGOT levels (p>0.05) based on variations in the dose and duration of administration.