Assessment of Antioxidant Activity of Stigma maydis Extract/Corn Silk Extract and Exploring its Efficacy Against Hyperglycemia in Diabetic Rats http://www.doi.org/10.26538/tjnpr/v7i11.4
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Abstract
Diabetes Mellitus (DM) is a major health issue characterized by hyperglycemia and is still on its upsurge. Corn silk extract (CSE) can be used as a remedy against hyperglycemia due to its rich antioxidant activity. This study was designed to assess the antioxidant potential of aqueous and ethanol corn silk extracts and to assess the efficacy of the selected extract against hyperglycemia in diabetic rats. For this purpose, aqueous and ethanol corn silk extracts were prepared and their antioxidant potential was assessed by performing TPC, DPPH, and ABTS assay. Based on the antioxidant tests results, ethanol corn silk extract was selected and given to rats. For the trial, 20 male rats with average weight 250 + 5 g were divided into three groups. Group 1 was non-diabetic, non-treated (control) while Group 2 and group 3 were diabetic, non-treated and diabetic, treated respectively. Group 2 and group 3 were injected 3 mL streptozotocin at the rate of 60 mg/kg with the final concentration of 5 mg/mL intraperitoneally. Group 3 received 1.5 mL ethanol corn silk extract while other two groups were given 1.5 mL water. Out of the three groups, Group 1 and group 2 had an inconsequential decline in mean blood glucose level at p < 0.05 while group 3 showed a significant decline in mean blood glucose level at p < 0.05. The polyphenols and antioxidants present in the corn silk extract impart functional as well as therapeutic properties to corn silk.
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