Pharmacological Potential of Andrographis paniculata (Burm. f.) Nees in Preventing Atherosclerosis: A Review
doi.org/10.26538/tjnpr/v5i11.3
Keywords:
Andrographis paniculata, Andrographolide, Atherosclerosis, PharmacologicalAbstract
Andrographis paniculata (Burm. f) Nees (AP) is a medicinal plant often found in Southeast Asian countries such as Indonesia, Malaysia, the Philippines, and China. AP has been used traditionally for increasing appetite, curing dysentery, fever, tuberculosis infection, cough, and runny nose. The aim of this article was to explore the potential of AP and its pharmacological effects in the prevention of atherosclerosis. Scientific data were gathered from articles published in the last 10 years in PubMed, Science Direct, Scopus, Web of Science, and Google. The inclusion criteria comprised journal articles describing the effects of AP, their equivalents, and derivatives on metabolic syndrome dyslipidemia, atherosclerosis, and other disorders. According to the findings of the literature research, AP contains diterpene lactones like andrographolide (Andro). The major active compounds in this plant are the Andro and analogues. These compounds are responsible for AP's pharmacological effects, one of which is anti-dyslipidemia. It is known that there is a positive correlation between anti-dyslipidemia and anti-atherosclerosis activity. Andro and its derivatives have a wide range of pharmacological actions, including anti-dyslipidemia and antioxidant activity, as well as other pharmacological properties such as anti-inflammatory activity. The review is supported by research from in vitro, in vivo, to clinical trials in humans. As a result of these properties, AP has a strong potential to prevent atherosclerosis.
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