Evaluation of The Toxic Effects of Ethanolic Leaf Extract of Tapinanthus cordifolius in Mice and Rats http://www.doi.org/10.26538/tjnpr/v7i10.37

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Published: Oct 29, 2023
Keywords:
sub-chronic toxicity, Acute toxicity, safety profile, Tapinanthus cordifolius

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Amarachi Chike-Ekwughe
Department of Biochemistry, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria.
Lucy B. John-Africa
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical and Research development, Idu Industrial Area, Abuja, Nigeria.
Abiodun H. Adebayo
Department of Biochemistry, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria.
Olubanke O. Ogunlana
Department of Biochemistry, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria.

Abstract

Tapinanthus cordifolius (TC), a hemiparasitic plant in the Loranthaceae family and the Tapinanthus genus, possesses numerous medicinal properties. In order to establish its medicinal quality and toxicity profile for appropriate application in traditional medicine. This study was designed to determine the safety profile of Tapinanthus cordifolius. Oral acute and sub-chronic toxicity studies of the ethanolic extract of Tapinanthus cordifolius were evaluated. The OECD (No. 423) limit test was followed to determine the LD50 in Swiss mice, while for the sub-chronic toxicity in Wistar rats, the OECD 407 guideline was followed. Acute toxicity studies in rats revealed no mortality or observable toxicity symptoms at doses of 2000, 5000 mg/kg for a 14-day observation period.  The 28-day toxicity tests of the extract showed no significant changes in body weight, food and water intake, urine output and faecal output. Haematological parameters, kidney function indices, and liver function parameters showed no significant effect after treatment with Tapinanthus cordifolius.  Histological examination of various organs showed no changes in the normal architecture of the cells in the tissues of the organs. Thus, based on the results, Tapinanthus cordifolius is considered relatively safe when administered orally at the dose tested.

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How to Cite
Chike-Ekwughe, A., John-Africa, L. B., Adebayo, A. H., & Ogunlana, O. O. (2023). Evaluation of The Toxic Effects of Ethanolic Leaf Extract of Tapinanthus cordifolius in Mice and Rats: http://www.doi.org/10.26538/tjnpr/v7i10.37. Tropical Journal of Natural Product Research (TJNPR), 7(10), 4965-4972. https://tjnpr.org/index.php/home/article/view/2850
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Vol. 7 No. 10 (2023): Tropical Journal of Natural Product Research (TJNPR)
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Author Biography

Amarachi Chike-Ekwughe, Department of Biochemistry, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria.

Department of Biochemistry, Faculty of Computing and Applied Sciences, Baze University, Abuja, Nigeria.

How to Cite

Chike-Ekwughe, A., John-Africa, L. B., Adebayo, A. H., & Ogunlana, O. O. (2023). Evaluation of The Toxic Effects of Ethanolic Leaf Extract of Tapinanthus cordifolius in Mice and Rats: http://www.doi.org/10.26538/tjnpr/v7i10.37. Tropical Journal of Natural Product Research (TJNPR), 7(10), 4965-4972. https://tjnpr.org/index.php/home/article/view/2850

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