Evaluation of Clitoria ternatea L. Flower Extract in Preventing Complications of Diabetes Mellitus http://www.doi.org/10.26538/tjnpr/v7i10.28

Abstract

Flavonoids and anthocyanins can be found in the Clitoria ternatea flower (C. ternatea). It has been demonstrated to lessen oxidative stress and to inhibit both the pancreatic enzyme a-amylase and the intestine's a-glucosidase. HbA1c is commonly used to detect glycemic levels, whereas malondialdehyde (MDA) is crucial for determining the potential risk of lipid peroxidation-related problems. This research assessed C. ternatea flower extract's (CTE) alter on fasting blood glucose, hemoglobin A1c (HbA1c), and MDA in Wistar rats with diabetes (DM) induced by streptozotocin-nicotinamide (STZ-NA). Thirty-six male Wistar rats were all used in this post-test-only control group experiment and allocated into six groups: standard control, DM control, DM+4,5 mg/kg acarbose, and DM+150 mg/kg CTE, DM+300 mg/kg CTE, and DM+600 mg/kg CTE, respectively. After 28 days of therapy, fasting blood glucose, HbA1c, and MDA plasma levels were assessed. DM+600 mg/kg CTE showed the lowest fasting blood glucose levels at 90.43±0.94 mg/dl. With a p-value of p<0.05, the Kruskal-Wallis test findings for fasting blood glucose and HbA1c levels demonstrated significant differences between the therapy groups. DM+600 mg/kg CTE showed the lowest levels of MDA of 3.13±0.09 nmol/ml and HbA1c of 26.04±0.13 ng/ml. One-way ANOVA findings for MDA levels had a p-value of p<0.05, indicating a significant difference between the treatment groups. According to the results, rats with diabetes induced by STZ-NA had lower fasting blood glucose levels, HbA1c, and MDA after receiving C. ternatea extract. Clitoria ternatea may have the ability to prevent DM problems.