Extraction and Characterization of the Gum Exudate of Anacardium occidentale for its potential as an Excipient in Drug Delivery Systems
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Abstract
Natural polymers are preferentially used over synthetics as excipients in formulation systems. Characterization of a polymer is essential to determine its suitability as an excipient. This study aimed at extraction and characterization of Anacardium occidentale (Anacardiaceae) gum for its potential as an excipient in drug delivery systems. Anacardium occidentale gum (AoG) sourced from South West Nigeria was extracted from the dried stem bark exudate gum using a modified established method. Physicochemical, pharmacognostical and solid state parameters were characterized. Extraction yield was high (72%w/w); it had desirable organoleptic properties, moisture content (9.32% ± 0.03), total ash values (2.00% ± 0.00), acidic pH (5.0), low swelling capacity (3.71 ± 0.04) swelling index (2.37 ± 0.073), hydrated to form gel (hydrogel). Phytochemical studies of AoG showed absence of tested bioactive substances; Magnesium ion was the predominant amongst its divalent metallic ions content, it did not contain hazardous lead ion. The FTIR spectrum established its polysaccharide nature as stretches of alkanes, alkynes, alcohols, phenols, phenyl, acetyl, carboxylic acids, carboxylate, ethers, aldehydes and ketones functional groups were observed, hence modifiable. Morphological structure revealed sharp irregular discrete particles with size range of 79.4 µm and 144 µm. Powder diffraction pattern showed the existence of two prominent peaks at 13.50 and 19.2 0 2 Theta, AoG thermal analysis showed that it is thermally stable.
AoG had good and desirable physicochemical properties such as hydrogel formation which could be employed either as a matrix layer former or carrier agent in drug deliver
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Hamman JH, Tarirai C. Functional excipients. Chem Today 2006; 24:57-62.
Malviya R, Srivastava P,Kulkarni GT.Applications of mucilages in drug delivery-a review. Adv Biol Res 2011; 5:1-7.
Prajapati VD, Jani GK, Moradiya NG, Randeria NP. Pharmaceutical applications of various natural gums, mucilages and their modified forms. Carhoydr Polym 2013; 92: 1685-1699.
Bhosale RR, Osmani RAM, Moin A. Natural Gums and Mucilages: A Review on Multifaceted Excipients in Pharmaceutical Science and Research. International Journal of Pharmacognosy and Phytochemical Research 2014; 15: 901-912.
Ngwuluka NC, Ochekpe NA, Okezie AI. Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery-A Review Polymers 2014; 6:1312-1332.
Anekant J, Yashwant G, Sanjay KJ. Perspectives of Biodegradable Natural Polysaccharides for Site-Specific Drug Delivery to the Colon. J Pharm Sci. 2007; 10:86-128.
Ofori Kwakye K, Asantewa Y, Kipo SL. Physiochemical and binding properties of Cashew tree gum in metronidazole tablet formulations. Int J Pharm Sci. 2010 2: 105-9.
Lima RDSN, Lima JR, De Salis CR, Moreira RDA Cashew-tree (Anacardium occidentale L.) exudate gum: a novel bioligand tool. Biotechnol. 2002; 45–53.
Olorunsola EO, Bhatia PG, Tytler BA, Adikwu MU,Thermochemical Properties of Hydrophilic Polymers from Cashew and Khaya Exudates and Their Implications on Drug Delivery. J Drug Delivery 2016; 7 pages. Article ID 7496585.
Ofori-Kwakye K, Amekyeh H, El-Duah M, Kipo SL. Mechanical and Tablet Coating Properties Of Cashew Tree (Anacardium Occidentale L) Gum-Based Films, Asian Journal of Pharmaceutical and Clinical Research 2012; 5:62-68.
Okoye EI, Anthony O, Onyekweli AO, Kunle OO.Solid State Characterization of Anacardium occidentale Gum. Research Journal of Applied Sciences, Engineering and Technology 2012; 4:3709-3716.
Kumar R, Patil MB, Patil SR Paschapur MS. Evaluation of Anacardium occidentale gum as gelling agent in aceclofenac gel. International J Pharm Tech Res. 2009; 1: 695 – 704
Abdulsamad A, Bhatia PG, Ojile JE. Emulsifying and suspending properties of cashew gum. Nig J Pharm Res. 2006; 5:40–47.
Pillai O, Panchagnula R, Polymers in drug delivery. Curr. Opin. Chem Biol. 2000; 5: 447–451.
Abreu FOMS, Oliveira EF, Paula, HLB de Paula, RCM. Chitosan/cashew gum nanogels for essential oil encapsulation. Carbohydrate Polymers 2012; 89: 1277-1282.
Okoye EI, Onyekweli AO, Kunle OO, Arhewoh MI. Brittle fracture index (BFI) as a tool in the classification, grouping and ranking of some binders used in tablet formulation: Lactose tablets Sci Res Essays. 2010; 5:500-506.
Azubuike CP, Rodriguez H, Okhamafe AO, Rogers RD. Physicochemical properties of maize cob cellulose powders reconstituted from ionic liquid solution. Cellulose. 2012; 19:425-433.
British Pharmacopoeia. Vol. 1-1V. Published by the department of health, London. British Pharmacopoeia Commission Office. London, UK: Her Majesty’s Stationery Office. 2009. 1917-1918p, 2851 p, A143 p, A291 p and A295 p.
Mahmud HS, Oyi AR, Allagh TS. Studies on some Physicochemical Properties of Khaya senegalensis gum. J Pharm Sci. 2008; 7:146‐152.
Kokate CK. Practical Pharmacognosy, (4th ed.) Delhi: Vallaph Prakashan. 1994. 107–111 p.
Khandelwal KR. Practical Pharmacognosy. (11th ed.). Pune, India: Nirali Prakashan. 2004. 149–153 p and 157–159 p.
United States Pharmacopeia, Inc.United States Pharmacopei 36-National Formulary 31. Rockville, MD: US Pharmacopeal Convention,Inc. 2013.
British Pharmacopoeia. Vol. 1-1V Published by the department of health, London. British Pharmacopoeia Commission Office. London, UK: Her Majesty’s Stationery Office. 2009. 1917-1918p, 2851 p, A143 p, A291 p and A295 p.
Isah AB, Olorunsola EO, Zaman YE. Physicochemical properties of Borassus aethiopum starch. Asian J Pharma Clin Res 2012; 5:132–134.
Barnes AR. Product stability and stability testing. In M.E. Aulton (Ed.) The Design and Manufacture of Medicine. Churchill Livingstone, Philadelphia, Pa, USA. 2007. 650–665 p.
Mu˜noz J, Rinc´on, F, Carmen Alfaro, M. et al “Rheological properties and surface tension of Acacia tortuosa gum exudate aqueous dispersions. Carbohydrate Polymers 2007; 70:198–205,
Gyedu-Akoto E, Oduro I, Amoah FM, Oldham JH, Ellis WO, Opoku-Ameyaw K, Bin Hakeem R. Physicochemical properties of cashew tree gum. Afr J Food Sci. 2008; 2:060 – 064.
Zakaria MB, Rahman ZA, Mahmod NNAN Solution properties of polysaccharides from Anacardium occidentale. Pertanika J Sci Technol. 1997; 5:69 – 76.
OforiKwakye K, Adom ENN, Mechanical properties of khaya and albizia films intended for Pharmaceutical coating. J Ghana Sci
Assoc 2007; 9: 43 – 53.
Pendyala V, Baburao C, Chandrasekhar KB. Studies on some physicochemical properties of leucaena leucocephala bark gum. J Adv Pharm Technol Res 2010; 1:253-259.
Nep EI, Conway BR. Characterization of Grewia Gum, a potential Pharmaceutical Excipient. J Excipients and Food Chem 2010; 1:30-40.
Chung HJ, Lee EJ, Lim, ST. Comparison in glass transition and enthalpy relaxation between native and gelatinized rice starches.
Carbohydrate Polymers 2002; 48:287–298.
Iqbal MS, Massey S, Akbar J, Ashraf CM, Masih R. Thermal analysis of some natural polysaccharide materials by isoconversional method. Food Chem. 2013; 140:178–182.
Horvat M, Mestrovic E, Danilovski A, Craig DQM. An investigation into the thermal behaviour of a model drug mixture with amorphous trehalose. Intl J Pharm. 2005; 294:1–10.
Mothe CG, De Souza IA, Calazans GM. Antitumor activity of cashew gum from Anacardium occidentale L. Agrofood Ind HiTech. 2008; 19: 50-52.
Shell JW. X-ray analysis, In L.G. Chatten (Ed.), Pharmaceutical Chemistry—Instrumental Techniques CBS Publishers and Distributors PVT Ltd, New Delhi, India. 2008; 371–406 p.
Danjo K, Hirasawa N, Okamoto H. Lactose as a low molecular weight carrier of solid dispersions for carbamazepine and ethenzamide. Chem Pharm Bull. 1999; 47: 417-420.
Najafabadi RA, Asgharian R, Tajerzadeh H, Gilani K, Vatanara A, Darabi M. The effects of fine lactose as a third component onaerosolization of cefotaxime sodium from dry powder formulations. Daru 2006; 14: 155-163.
Hulse WL, Forbes RT, Bonner MC, Getrost M. Influence of protein on mannitol polymorphic form produced during co-spray drying. Intl J Pharm. 2009; 382:67-72.
Malik H, Gupta N , Sarkar A. Anisotropic electrical conduction in gum Arabic-a biopolymer. Mat. Sci. Eng. C 2002; 20: 215-218.
Murali-Mohan BGV, Prasad DS, Ramana MKV. Evaluation of modified gum karaya as carrier for the dissolution enhancement of poorly water soluble drug nimodipine. Int. J. Pharm 2002; 234: 1-17.
Reddy TT, Shekharam T. Free Radical Degradation of Guar Gum. Polym. Degrad. Stabil 2004; 86:455-459.
Odeku OA, Oluyemisi AB, Vivek RS, Kumar R. Characterization and evaluation of Terminalia randii gum as a binder in carvedilol tablet formulation Acta Pharmaceutica Sciencia, 2010; 52:254-262