Investigations of Ameliorative Potentials Extract of P. pellucida on Salt - Fructose Induced Dyslipidemia in Wistar Rats http://www.doi.org/10.26538/tjnpr/v7i9.40
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Abstract
he study was undertaken to investigate the effect of extracts of P. pellucida on salt-fructose induced dyslipidemia in rats with a view to validating its consumption for the treatment and management of hyperlipidemia, obesity and high blood pressure. Dyslipidemia was induced in rats by oral administration of high concentrations of salt (NaCl, 18% (w/v)) and fructose (10%
(w/v) for 21 days. The induced rats (30) were randomly allotted into 5 groups of 6 rats per group . Test groups were treated consistently for 21 days with either 250 mg/kg bwt, 500 mg/kg bwt of Peperomia pellucida methanol extract (PPME) or standard drug (Atorvastatin, 0.6 mg/kgbwt). On day 22, the rats were anesthetized with diethyl ether and blood and liver collected for biochemical analyses. Plasma lipid profile parameters (Total cholesterol, LDL, HDL and VLDL cholesterol), atherogenic indices (atherogenic index, Coronary risk index I & II) and enzymatic / non-enzymatic antioxidants (Superoxide dismutase, Peroxidase and Glutathione), were evaluated using standard procedures. Results reveal significant increase in lipid profiles and metabolites, and significant decrease in the antioxidant enzymes of test animals compared with the control as a result of induction with high salt and fructose solution. However, the altered biochemical parameters were restored in the groups treated with PPME. The study suggests that P. pellucida may be of good value in the prevention and management of dyslipidaemia, a risk factor for cardiovascular diseases.
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