Stress Responses and Alteration in Membrane-Bound Phosphatase Activities in Wistar Rats Treated with Adrenaline: The role of Senna occidentalis Extract
doi.org/10.26538/tjnpr/v5i12.14
Keywords:
Stress, Adrenaline, S. occidentalis, Na -K -ATPase, Ca2 - Mg2 - ATPaseAbstract
The cardiotoxic effect of Adrenaline has been recounted in several studies but its effect on membrane-bound phosphatase has not been known yet. The study assessed the biochemical changes and the alterations in membrane-bound phosphatase activities after the administration of adrenaline in Wistar rats. Adult rats were treated with Adrenaline (Adr) 2 mg/kg body weight and its effect on creatine kinase-MB, lactate dehydrogenase (LDH) and electrolyte levels (Na+ , K+ , Ionized Ca, Total Ca, Mg2+, PO4) were evaluated. Other parameters investigated include the activities of sodium/potassium adenosine triphosphate (Na+-K+-ATPase), calcium and magnesium dependent adenosine triphosphate (Ca2+ - Mg2+ - ATPase). An impairment in the activities of sodium/potassium adenosine triphosphate (Na+-K+-ATPase), calcium and magnesium dependent adenosine triphosphate (Ca2+ - Mg2+ - ATPase) in the vascular tissues of adrenaline treated rats was recorded. Administration of propranolol and Coffee Senna (S. occidentalis) extract was able to reverse the changes in a dose-dependent manner. The result also revealed a significant rise (P˂0.05) in the levels of serum creatine kinase-MB and lactate dehydrogenase (LDH) after adrenaline treatment, a significant decrease in serum electrolytes (sodium, calcium, magnesium, phosphate ions), and an insignificant decrease in the levels ofpotassium ions compared to controls. The changes could be an outcome of the alteration in transmembrane transport mechanisms.
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