Chemical and Pharmacological Potential of <i>Adiantum philippense</i> Linn and Further Molecular Simulation Study of Its Compounds Against COX-2: An Unexplored Medicinal Fern


  • Taslima Akhter Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Nuraya Y. Bristy Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Md. E. Shikdar Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Ashit K. Dutta Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Dipto K. Sarker Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208
  • Khondoker S. Ahmed Chemical Research Division, BCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh
  • Hemayet Hossain Chemical Research Division, BCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh
  • Jamil A. Shilpi Chemical Research Division, BCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh
  • Shaikh J. Uddin Pharmacy Discipline, Life Science School, Khulna University, Khulna-9208


molecular simulation, analgesic activity, medicinal fern, Adiantum philippense


Adiantum philippense Linn (Pteridiaceae), commonly known as “Goyalelata” which has been traditionally used to cure of different diseases including dysentery, ulcers, fevers, cooling and elephantiasis. This study aims to summarize the phytoconstituents reported for A. philippense and its pharmacological activities as well as further in-silico molecular dynamics studies to identify active compounds against COX-2 enzyme as potent analgesic. The data for this study were collected using online databases such as Google Scholar, PubMed, Scopus and Web of Science. Previous studies have established that a number of phytochemicals have been identified
from this plant including phenolic compounds (caffeic acid, chlorogenic acid, phloroglucino, esculetin), flavonoids (rutin, quercetin, luteolin), terpenoids (ursolic acid, botulin, carvone and glycyrrhetinic acid). Literature study demonstrated that A. philipense has the potential analgesic, antioxidant, antimicrobial, cytotoxic and hepatoprotective effects in both in-vivo and in-vitro test systems. The plant can act as suitable candidate for the biosynthesis of nanoparticles and application as a therapeutic purpose. The molecular docking analysis of its reported phytoconstituents with CoX-2 showed that quercetin, and luteolin exhibited the most favorablebinding affinity with a value of -8.1 and -8.0 kcal/mol, respectively. Further molecular dynamics study revealed that quercetin was the most promising anti-inflammatory compounds present in A. philippense confirmed by the RMSD, RMSF, Rg, SASA and hydrogen bond analysis. In summary, it is proved that A. philippense one of the potential traditional medicinal fern that possess bioactive compounds which could be useful in the prevention of pain and inflammation.


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How to Cite

Akhter, T., Bristy, N. Y., Shikdar, M. E., Dutta, A. K., Sarker, D. K., Ahmed, K. S., … Uddin, S. J. (2023). Chemical and Pharmacological Potential of <i>Adiantum philippense</i> Linn and Further Molecular Simulation Study of Its Compounds Against COX-2: An Unexplored Medicinal Fern: Tropical Journal of Natural Product Research (TJNPR), 7(9), 3842–3855. Retrieved from

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