Antidepressant Activity of Methanol Extract of Tapinanthus globiferus (A. Rich) Tiegh in Swiss Mice doi.org/10.26538/tjnpr/v5i12.13
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Abstract
Depression has been a global public health issue for a while and has prompted many researches to develop safer and more effective treatment of depressive illness. It affects how an individual feel, think, relate to others and handle daily activities. The aim of this study is to evaluate the antidepressant activity of the methanol extract of Tapinanthus globiferus in acute model of depression in mice. Phytochemical screening was carried out to identify the different phytochemicals present in the extract. Acute toxic effect of the extract was determined using OECD method. The antidepressant activity of the extract was evaluated using tail suspension test, forced swim tests and confirmed with the open field test. The methanol extract of T. globiferus contains some phytochemicals some of which have been shown to have antidepressant activity, it was also shown to be practically nontoxic using the OECD guidelines. The extract significantly reduced the immobility time in Tail suspension test but not in the forced swim test. In addition, locomotor activity in open filed test was not significantly affected implying that the extracts activity is not due to locomotor stimulation The result of the study revealed that the methanol extract of T. globiferus has antidepressant activity.
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