Antidepressant Activity of Methanol Extract of Tapinanthus globiferus (A. Rich) Tiegh in Swiss Mice
doi.org/10.26538/tjnpr/v5i12.13
Keywords:
Tapinanthus globiferus, depression, antidepressant, immobility, forced swimming, tail suspensionAbstract
Depression has been a global public health issue for a while and has prompted many researches to develop safer and more effective treatment of depressive illness. It affects how an individual feel, think, relate to others and handle daily activities. The aim of this study is to evaluate the antidepressant activity of the methanol extract of Tapinanthus globiferus in acute model of depression in mice. Phytochemical screening was carried out to identify the different phytochemicals present in the extract. Acute toxic effect of the extract was determined using OECD method. The antidepressant activity of the extract was evaluated using tail suspension test, forced swim tests and confirmed with the open field test. The methanol extract of T. globiferus contains some phytochemicals some of which have been shown to have antidepressant activity, it was also shown to be practically nontoxic using the OECD guidelines. The extract significantly reduced the immobility time in Tail suspension test but not in the forced swim test. In addition, locomotor activity in open filed test was not significantly affected implying that the extracts activity is not due to locomotor stimulation The result of the study revealed that the methanol extract of T. globiferus has antidepressant activity.
References
De la Serna JM. The Origins of Depression. J.M. De la Serna, Depression, when sadness becomes a disease. Hackensack: Babelcube Inc. 2019; 39-44p.
World Health Organization (WHO). Depression. [Online]. 2016 [Cited 2018 Jun 16] https://www.who.int/newsroom/factsheets/detail/depression
National institute of mental health ‘Depression’ [Online] 2018 [Cited 2018 Aug 18]. Available from: https://www.nimh.nih.gov/health/topics/depression/index.shtml.
Catena-Dell’Osso M, Bellantuono C, Consoli G, Baroni S, Rotella F, Marazziti D. Inflammatory and neurodegenerative pathways in depression: a new avenue for antidepressant development? Curr Med Chem. 2011; 18(2):245-255.
Hasler G. Pathophysiology of depression: do we have any solid evidence of interest to clinicians? World Psychiatry.2010; 9(3):155-161.
Lowe P, Krivoy A, Porffy L, Henriksdottir E, Eromona W, Shergill SS. When the drugs don't work: treatment-resistant schizophrenia, serotonin and serendipity. Ther Adv Psychopharmacol. 2018; 8(1):63-70.
Watson MD. Mistletoe In: A keystone Resource in Forest and Woodlands Worldwide’, Annu. Rev Ecol Syst. 2001; 32:219-249.
Jeremiah C, Katsayal UA, Nuhu A, Anafi SB, Ibrahim MA, Nuhu HD Phytochemical Screening and Anti-Inflammatory Studies of T. globiferus (A. Rich) Teigh. Leaves Tree Extracts. Pharm Sci. 2019; 25(2):124-131.
Shehu A, Magaji MG, Yau J, Ahmed A. Ethno-botanical survey of medicinal plants used for the management of depression by Hausa tribes of Kaduna State, Nigeria. Med Plant Res. 2017; 11(36):562-567.
Trease E and Evans WC. A Textbook of Pharmacognosy. (13th Ed.) London, UK: Bailliere Tindall; 1989; 61–62p.
OECD. Acute Oral Toxicity: Up-and-Down Procedure, OECD Guidelines for the Testing of Chemicals, Test No. 425 Section 4, OECD Publishing, Paris 2008.
Rodrigues AL, Silva GL, Matteussi AS. Involvement of monoaminergic system in the antidepressant-like effect of the hydroalcoholic extract of Siphocampylus verticillatus. Life Sci. 2002; 70(12):1347-1358.
Porsolt RD, Bertin A, Jalfre M. Behavioral Despair in Mice: A Primary Screening Test for Antidepressants. Eur J Pharmacol. 1978; 51(3):291-294.
Rex A, Voigt JP, Voits M, Fink H. Pharmacological evaluation of a modified open field test sensitive to anxiolytic drugs Pharmacol Biochem Behav J. 1998; 59:677-683.
Simeon K, Adesina HC, Illoh II, Johnny and Imo E. Jacobs. African mistletoes (loranthaceae); ethnopharmacology, chemistry and medicinal values: an update. Afr J Trad Compl Altern Med. 2013; 10(3):161-170.
Razafsha M, Behforuzi H, Harati H, Wafai RA, Khaku A, Mondello S, Gold MS, Kobeissy FH. An updated overview of animal models in neuropsychiatry. Neurosci. 2013; 240:204-218
Can A, Dao DT, Terrillion CE, Piantadosi SC, Bhat S, Gould TD. The tail suspension test. J Vis Exp. 2012; (59):e3769.
Cryan JF and Holmes A. The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov. 2005; 4(9):775-790.
Borsini F and Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacol (Berl). 1988; 94(2):147-160
Refaey HEL and Amri HS. Effects of antidepressants on behavioral assessment in adolescent rats. Bahrain Med Bull 2014; 33:1-12.
Refaey HEL and Amri HS. Effects of Antidepressants on Behavioral Assessment in Adolescent Rats. Bahrain Med Bull. 2011; 33(2):83-89.
Fekadu N, Shibeshi W, Engidawork E. Evaluation of the Antidepressant-like Activity of the Crude Extract and Solvent Fractions of Rosa Abyssinica Lindley (Rosaceae) Using Rodent Models of Depression. J Clin Exp Pharmacol. 2016; 6(3):1-7.
Duman CH. Models of depression. Vitam Horm. 2010; 82:1-21.
Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev. 2005; 29(4-5):571-625.
Yan HC, Cao X, Das M, Zhu XH, Gao TM. Behavioral animal models of depression. Neurosci Bull. 2010; 26(4):327-337.
Umarudeen AM and Magaji MG. Appraising the Neurobehavioural Toxicity Potential of Aqueous Methanol Leaf Extract of Tapinanthus globiferus growing on Azadirachta indica. Int Neuropsych Dis J. 2021; 14(2):1-11.
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