Anti-inflammatory and Neuroprotective Effects of Lactobacillus Strains Contribute to its Antidepressant-Like Property Against Chronic Unpredictable Stress-Induced Behavioural Abnormalities in Mice http://www.doi.org/10.26538/tjnpr/v7i8.36
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Abstract
Depression is one of the most worrisome disorders of the central nervous system (CNS). Recently, more researchers have delved into studying the links between the gut microbiota and psychiatric disorders such as depression, anxiety, and cognitive impairments such as amnesia. With this novel angle came the research into probiotics, the gut microbiota-modifying bacteria. This study was therefore designed to evaluate the neuroprotective effect of specific probiotic strains on chronic unpredictable stress induced depressive symptoms in mice. Thirty-five mice (20-30 g) were shared into five groups randomly. Groups 1 and 2 received vehicle (10 mL/kg), groups 3 and 4 received probiotics (10 mL/kg), and group 5 received fluoxetine (10 mg/kg). Only groups 2, 3 and 5 were exposed to an unpredictable order of chronic mild stress daily for twenty-one (21) days. Afterward, behavioural, and biochemical assays were carried out. The results revealed that chronic unpredictable stress caused significant (p<0.05) elevation in depressive-like behaviours, increased
the production of proinflammatory cytokines and even signalled hippocampal neurodegeneration. However, a significant (p<0.05) reversal of these effects was observed in the probiotics-treated groups as effectively as the fluoxetine group. It can be concluded that anti-inflammatory and neuroprotective effects of lactobacillus strains may contribute to its antidepressive-like action against CUS-induced depression in mice.
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