Evidence of Nitric Oxide-Cyclic GMP-Potassium Channels Involvement in Antinociceptive Activity of Chalcone Derivative; 3-(2,5-dimethoxy phenyl)-1-(5-methyl furan-2-yl) prop-2-en-1 (DMPF-1) Using Behaviour-Induced Nociception

http://www.doi.org/10.26538/tjnpr/v7i8.25

Authors

  • Noor A. A. Bakar Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Malaysia.
  • Noor A. Suliman Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Malaysia.
  • Mohd R. Sulaiman Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
  • Muhammad N. Akhtar Department of Chemistry, Ghazi University, Dera Ghazi Khan, Pakistan

Keywords:

abdominal writhing, guanosine monophosphate, soluble guanylyl cyclase, Voltage gated potassium channel, ATP dependent potassium channel, L-arginine, nitric oxide, DMPF-1, 3-(2,5-dimethoxy phenyl)-1-(5-methyl furan-2-yl) prop-2-en-1

Abstract

Chalcones are interesting and versatile compounds due to their various pharmacological properties. Important biological activities of chalcones have been reported for decades using different experimented models. The 3-(2,5-dimethoxy phenyl)-1-(5-methyl furan-2-yl) prop-2-en- 1 (DMPF-1) is one of the chalcone analogues that has reported to have analgesic properties despite of it published safety profile. The present study examined the possible anti nociceptive modulatory activity exerted by the DMPF-1 compound in behavioural-induced nociception in animal model using Institute of Cancer Research (ICR) mice. Administration of DMPF-1 compound at a dose
of 1 mg/kg intraperitoneally exerted a pronounced antinociceptive effect against acetic acidinduced nociception. The antinociceptive effect of the DMPF-1 compound significantly (P<0.001) was reversed by the pre-treatment of the animals with the nitric oxide precursor; L-arginine (100mg/kg; i.p), and the soluble guanylyl cyclase inhibitor; oxadiazole (4,3-a) quinoxaline-1-one (ODQ) (2.0 mg/kg; i.p.). A similar inhibitory pattern was observed upon the challenge of DMPF- 1 against two potassium channel inhibitors, glibenclamide (10 mg/kg; i.p.) and tetraethylammonium (4 mg/kg; i.p.). Overall, these findings suggest the possible contribution of
nitric oxide-cyclic GMP-potassium signalling pathway in the antinociceptive activity exhibited by the DMPF-1 compound. This chalcone analogue and its molecular structure might be further investigated as a model that could be used to obtain more potent analgesic agents. 

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Published

2023-08-31

How to Cite

Bakar, N. A. A., Suliman, N. A., Sulaiman, M. R., & Akhtar, M. N. (2023). Evidence of Nitric Oxide-Cyclic GMP-Potassium Channels Involvement in Antinociceptive Activity of Chalcone Derivative; 3-(2,5-dimethoxy phenyl)-1-(5-methyl furan-2-yl) prop-2-en-1 (DMPF-1) Using Behaviour-Induced Nociception: http://www.doi.org/10.26538/tjnpr/v7i8.25. Tropical Journal of Natural Product Research (TJNPR), 7(8), 3735–3740. Retrieved from https://tjnpr.org/index.php/home/article/view/2449