Evidence of Nitric Oxide-Cyclic GMP-Potassium Channels Involvement in Antinociceptive Activity of Chalcone Derivative; 3-(2,5-dimethoxy phenyl)-1-(5-methyl furan-2-yl) prop-2-en-1 (DMPF-1) Using Behaviour-Induced Nociception http://www.doi.org/10.26538/tjnpr/v7i8.25
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Abstract
Chalcones are interesting and versatile compounds due to their various pharmacological properties. Important biological activities of chalcones have been reported for decades using different experimented models. The 3-(2,5-dimethoxy phenyl)-1-(5-methyl furan-2-yl) prop-2-en- 1 (DMPF-1) is one of the chalcone analogues that has reported to have analgesic properties despite of it published safety profile. The present study examined the possible anti nociceptive modulatory activity exerted by the DMPF-1 compound in behavioural-induced nociception in animal model using Institute of Cancer Research (ICR) mice. Administration of DMPF-1 compound at a dose
of 1 mg/kg intraperitoneally exerted a pronounced antinociceptive effect against acetic acidinduced nociception. The antinociceptive effect of the DMPF-1 compound significantly (P<0.001) was reversed by the pre-treatment of the animals with the nitric oxide precursor; L-arginine (100mg/kg; i.p), and the soluble guanylyl cyclase inhibitor; oxadiazole (4,3-a) quinoxaline-1-one (ODQ) (2.0 mg/kg; i.p.). A similar inhibitory pattern was observed upon the challenge of DMPF- 1 against two potassium channel inhibitors, glibenclamide (10 mg/kg; i.p.) and tetraethylammonium (4 mg/kg; i.p.). Overall, these findings suggest the possible contribution of
nitric oxide-cyclic GMP-potassium signalling pathway in the antinociceptive activity exhibited by the DMPF-1 compound. This chalcone analogue and its molecular structure might be further investigated as a model that could be used to obtain more potent analgesic agents.
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