Evaluation of Analgesic Effects of Herbal Formula Qt-2 on Experimental Mice Model http://www.doi.org/10.26538/tjnpr/v7i8.16
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Abstract
Osteoarthritis is a prevalent condition worldwide, causing significant pain and disability. The use of a traditional Vietnamese remedy, QT-2 decoction, has been employed for its potential therapeutic effects on osteoarthritis. However, there is a lack of scientific evidence supporting its analgesic properties. Therefore, the aim of this research was to assess the analgesic effect of QT- 2 decoction in mice models. The study evaluated both the central and peripheral analgesic effects of QT-2 decoction using the hot plate test and the writhing test with acetic acid, respectively. The results revealed analgesic effects of QT-2 decoction. According to statistically significant results, QT-2 administration at doses of 21.4 g/kg/day and 42.8 g/kg/day demonstrated an analgesic effect on hot plate and delayed the onset of colic in the acetic acid-induced pain model by exerting peripheral analgesic effects. These findings indicate the potential of QT-2 decoction to alleviate pain both centrally and peripherally suggesting that QT-2 decoction holds promise as an effective treatment option for pain management.
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Glyn-Jones S, Palmer AJR, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ: Osteoarthritis. Lancet 2015; 386:376–87
Long H, Liu Q, Yin H, Wang K, Diao N, Zhang Y, Lin J, Guo A: Prevalence Trends of Site-Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019. Arthritis Rheumatol 2022; 74:1172–83
Liang Y, Xu Y, Zhu Y, Ye H, Wang Q, Xu G: Efficacy and Safety of Chinese Herbal Medicine for Knee Osteoarthritis: Systematic Review and Meta-analysis of Randomized Controlled Trials. Phytomedicine 2022; 100:154029
Lindler BN, Long KE, Taylor NA, Lei W: Use of Herbal Medications for Treatment of Osteoarthritis and Rheumatoid Arthritis. Medicines (Basel) 2020; 7:67
Zhang P, Li K, Kamali A, Ziadlou R, Ahmad P, Wang X, Richards RG, Alini M, Basoli V, Li Z, Grad S: Small molecules of herbal origin for osteoarthritis treatment: in vitro and in vivo evidence. Arthritis Research & Therapy 2022; 24:105
Dung TN, Bodeker G: Tue Tinh: founder of Vietnamese traditional medicine. J Altern Complement Med 2001; 7:401–3
Wang Q-S, Gao T, Cui Y-L, Gao L-N, Jiang H-L: Comparative studies of paeoniflorin and albiflorin from Paeonia lactiflora on anti-inflammatory activities. Pharm Biol 2014; 52:1189–95
Boyd A, Bleakley C, Hurley DA, Gill C, Hannon-Fletcher M, Bell P, McDonough S: Herbal medicinal products or preparations for neuropathic pain. Cochrane Database Syst Rev 2019; 4:CD010528
Yang H, Cheng X, Yang Y-L, Wang Y-H, Du G-H: Ramulus Cinnamomi extract attenuates neuroinflammatory responses via downregulating TLR4/MyD88 signaling pathway in BV2 cells. Neural Regen Res 2017; 12:1860–4
Ghasemian M, Owlia S, Owlia MB: Review of AntiInflammatory Herbal Medicines. Adv Pharmacol Sci 2016; 2016:9130979
Markus J, Wang D, Kim Y-J, Ahn S, Mathiyalagan R, Wang C, Yang DC: Biosynthesis, Characterization, and Bioactivities Evaluation of Silver and Gold Nanoparticles Mediated by the Roots of Chinese Herbal Angelica pubescens Maxim. Nanoscale Res Lett 2017; 12:46
Yang R, Yuan B-C, Ma Y-S, Zhou S, Liu Y: The antiinflammatory activity of licorice, a widely used Chinese herb. Pharm Biol 2016; 55:5–18
Chen Z, Li W, Quan L, Zhou H, Zhao Y, Zhang X, Hu L, Hu C: The Effects of Curcumae Longae Radix, Curcuma phaeocaulis Radix and Their Processed Products on Epo/EpoR Pathway and CD62p. Front Pharmacol 2018; 9:736
Administration of Science Technology and Training (Vietnam).
Tran Y, Tram T, Huu Du N, Nguyen P, Kien N, Duong C, Tran MH, Hoang T, Minh H: Effects of Ganoderma LucidumExtract on Morphine- Induced Addiction and Memory Impairment in Mice. Biointerface Research in Applied Chemistry 2022; 12:1076–84
Pham XP, Le MH, Nguyen MP, Nguyen HN, Nguyen DB: Therapeutic Effects of Y10 Capsule on Male Patients with Semen Quality Impairment: doi.org/10.26538/tjnpr/v5i10.17. Tropical Journal of Natural Product Research (TJNPR) 2021; 5:1803–7
Woolfe G, Macdonald AD: The evaluation of the analgesic action of pethidine hydrochloride (demerol). J Pharmacol Exp Ther 1944:300–7
Abdullahi ID, Yaro AH, Nazifi AB: Preliminary Studies on the Anti-Inflammatory and Analgesic Effects of Methanol Leaf Extract of Ficus asperifolia Miq: doi.org/10.26538/tjnpr/v4i3.5. Tropical Journal of Natural Product Research (TJNPR) 2020; 4:85–90
Koster R, Anderson M, Debeer F: Acetic acid for analgetic screening. Fed Proc 1959:412–7
Lee J, Lim S: Anti-inflammatory, and anti-arthritic effects by the twigs of Cinnamomum cassia on complete Freund’s adjuvant-induced arthritis in rats. Journal of Ethnopharmacology 2021; 278:114209
Liao J-C, Deng J-S, Chiu C-S, Hou W-C, Huang S-S, Shie P-H, Huang G-J: Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo. Evid Based Complement Alternat Med 2012; 2012:429320
Gao J, Yang X, Yin W: From Traditional Usage to Pharmacological Evidence: A Systematic Mini-Review of Spina Gleditsiae. Evid Based Complement Alternat Med 2016; 2016:3898957
Li KK, Zhou X, Wong HL, Ng CF, Fu WM, Leung PC, Peng G, Ko CH: In vivo and in vitro anti-inflammatory effects of Zao-Jiao-Ci (the spine of Gleditsia sinensis Lam.) aqueous extract and its mechanisms of action. Journal of Ethnopharmacology 2016; 192:192–200
Xi S-Y, Yue L, Qian L: Essentials for Clinical Practice with Traditional Chinese Medicine. 2015
Liu Z: Basic Principles of CM Herbal Formulation, Essentials of Chinese Medicine. Edited by Liu Z. London, Springer, 2010, pp 706–14 doi:10.1007/978-1-84882-112-5_19
Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q: Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model. Front Pharmacol 2020; 11:45