Evaluation of Analgesic Effects of Herbal Formula Qt-2 on Experimental Mice Model



  • Tuan T. Vo Department of Traditional Medicine, Ho Chi Minh City University Medicine and Pharmacy, Ho Chi Minh, Vietnam
  • Thuy T. Lam Kien Giang Traditional Medicine and Pharmacy Hospital, Kien Giang, Vietnam
  • Tuan A. Phan Ha Noi college of Pharmacy, Ha Noi, Vietnam
  • Hoang M. Le Department of Traditional Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam


herbal medicine, traditional medicine, QT-2, Analgesic effect


Osteoarthritis is a prevalent condition worldwide, causing significant pain and disability. The use of a traditional Vietnamese remedy, QT-2 decoction, has been employed for its potential therapeutic effects on osteoarthritis. However, there is a lack of scientific evidence supporting its analgesic properties. Therefore, the aim of this research was to assess the analgesic effect of QT- 2 decoction in mice models. The study evaluated both the central and peripheral analgesic effects of QT-2 decoction using the hot plate test and the writhing test with acetic acid, respectively. The results revealed analgesic effects of QT-2 decoction. According to statistically significant results, QT-2 administration at doses of 21.4 g/kg/day and 42.8 g/kg/day demonstrated an analgesic effect on hot plate and delayed the onset of colic in the acetic acid-induced pain model by exerting peripheral analgesic effects. These findings indicate the potential of QT-2 decoction to alleviate pain both centrally and peripherally suggesting that QT-2 decoction holds promise as an effective treatment option for pain management. 

Author Biography

Tuan A. Phan, Ha Noi college of Pharmacy, Ha Noi, Vietnam

Department of Traditional Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam


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How to Cite

Vo, T. T., Lam, T. T., Phan, T. A., & Le, H. M. (2023). Evaluation of Analgesic Effects of Herbal Formula Qt-2 on Experimental Mice Model: http://www.doi.org/10.26538/tjnpr/v7i8.16. Tropical Journal of Natural Product Research (TJNPR), 7(8), 3671–3675. Retrieved from https://tjnpr.org/index.php/home/article/view/2409