Evaluation of Analgesic Effects of Herbal Formula Qt-2 on Experimental Mice Model http://www.doi.org/10.26538/tjnpr/v7i8.16
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Abstract
Osteoarthritis is a prevalent condition worldwide, causing significant pain and disability. The use of a traditional Vietnamese remedy, QT-2 decoction, has been employed for its potential therapeutic effects on osteoarthritis. However, there is a lack of scientific evidence supporting its analgesic properties. Therefore, the aim of this research was to assess the analgesic effect of QT- 2 decoction in mice models. The study evaluated both the central and peripheral analgesic effects of QT-2 decoction using the hot plate test and the writhing test with acetic acid, respectively. The results revealed analgesic effects of QT-2 decoction. According to statistically significant results, QT-2 administration at doses of 21.4 g/kg/day and 42.8 g/kg/day demonstrated an analgesic effect on hot plate and delayed the onset of colic in the acetic acid-induced pain model by exerting peripheral analgesic effects. These findings indicate the potential of QT-2 decoction to alleviate pain both centrally and peripherally suggesting that QT-2 decoction holds promise as an effective treatment option for pain management.
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