Antioxidant and Anti-Inflammatory Activities of Saponins Extracted from Marrubium vulgare L. Collected in Fez-Meknes Region in Morocco http://www.doi.org/10.26538/tjnpr/v7i8.6
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Abstract
This study concentrates on the importance of saponins present in Marrubium vulgare L. which is a medicinal plant used mainly in Morocco for neurosedative and anti-inflammatory treatment. To prove its importance, in a phytochemical study, antioxidant and anti-inflammatory activities were determined. The phytochemical analysis allowed isolating saponins compounds from the plant leaves, with foam index equal to 550. Saponins compounds extraction was conducted by three different methods. Results showed a yield of 2.87±0.21% by maceration after fat elimination extraction (D), 6.28±0.28% by maceration extraction (E) and 9.86±0.14% by soxhlet
extraction(S). Antioxidant activity was done with FRAP and TAC methods. At 0.5 mg/ml, the three extracts exhibited high antioxidant activity, namely ethanolic extract (E), which presented the significant highest value with 9033.58 AAE/1gDM by TAC assay, and 2361.57 AAE/1gDM by FRAP method. In the anti-inflammatory activity, the (E) extract showed significant inhibition at 500 mg/kg and 180 min after formol-injected 96.64% compared to Aspirin which showed an inhibition of 59.27% at 150 mg/Kg. The results have shown the significance of the medicinal plant Marrubium vulgare L. and its remarkable biological activities, which are related especially to saponins.
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