Antioxidant and Anti-Inflammatory Activities of Saponins Extracted from Marrubium vulgare L. Collected in Fez-Meknes Region in Morocco http://www.doi.org/10.26538/tjnpr/v7i8.6

Main Article Content

Abdellatif Amnay
Taha Ouriagli
Sidi M. Raoui
Faouzi Errachidi
Fouad O. Chahdi
Bahia Bennani
Youssef K. Rodi
Rachida Chabir

Abstract

This study concentrates on the importance of saponins present in Marrubium vulgare L. which is a medicinal plant used mainly in Morocco for neurosedative and anti-inflammatory treatment. To prove its importance, in a phytochemical study, antioxidant and anti-inflammatory activities were determined. The phytochemical analysis allowed isolating saponins compounds from the plant leaves, with foam index equal to 550. Saponins compounds extraction was conducted by three different methods. Results showed a yield of 2.87±0.21% by maceration after fat elimination extraction (D), 6.28±0.28% by maceration extraction (E) and 9.86±0.14% by soxhlet
extraction(S). Antioxidant activity was done with FRAP and TAC methods. At 0.5 mg/ml, the three extracts exhibited high antioxidant activity, namely ethanolic extract (E), which presented the significant highest value with 9033.58 AAE/1gDM by TAC assay, and 2361.57 AAE/1gDM by FRAP method. In the anti-inflammatory activity, the (E) extract showed significant inhibition at 500 mg/kg and 180 min after formol-injected 96.64% compared to Aspirin which showed an inhibition of 59.27% at 150 mg/Kg. The results have shown the significance of the medicinal plant Marrubium vulgare L. and its remarkable biological activities, which are related especially to saponins. 

Article Details

How to Cite
Amnay, A., Ouriagli, T., Raoui, S. M., Errachidi, F., Chahdi, F. O., Bennani, B., … Chabir, R. (2023). Antioxidant and Anti-Inflammatory Activities of Saponins Extracted from Marrubium vulgare L. Collected in Fez-Meknes Region in Morocco: http://www.doi.org/10.26538/tjnpr/v7i8.6. Tropical Journal of Natural Product Research (TJNPR), 7(8), 3613–3619. Retrieved from https://tjnpr.org/index.php/home/article/view/2399
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Author Biographies

Abdellatif Amnay, Human Pathology, Biomedicine and Environment Laboratory, Faculty of Medicine, Pharmacy and dentistry, Sidi Mohamed Ben Abdellah University, Fez, Morocco

Laboratory of Functional Ecology and Engineering Environment, Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University, Fez, Morocco

Taha Ouriagli, Human Pathology, Biomedicine and Environment Laboratory, Faculty of Medicine, Pharmacy and dentistry, Sidi Mohamed Ben Abdellah University, Fez, Morocco

Laboratory of Functional Ecology and Engineering Environment, Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University, Fez, Morocco

Sidi M. Raoui, Laboratory of Functional Ecology and Engineering Environment, Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University, Fez, Morocco

Higher Institute of Nursing professions and Health Techniques of Fez-Meknes, Morocco

Faouzi Errachidi, Human Pathology, Biomedicine and Environment Laboratory, Faculty of Medicine, Pharmacy and dentistry, Sidi Mohamed Ben Abdellah University, Fez, Morocco

Laboratory of Functional Ecology and Engineering Environment, Faculty of Sciences and Technologies, Sidi Mohamed Ben Abdellah University, Fez, Morocco

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