Acute Safety Assessment of Ethanol Leaves Extract of Cemba (Acacia rugata L.) on The Kidney in Male Wistar Rats http://www.doi.org/10.26538/tjnpr/v7i7.12
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Abstract
This study aimed to assess the safety of acute oral administration of leaves extract of cemba (Acacia rugata L.) in male rats. The rats were grouped and administered 250, 500, and 750 mg/kg of the extract. The animals were observed for fourteen days for mortality in all treatment groups. Blood samples were taken, and the kidneys were excised for histopathological examination. None
of the animals died. A significant (p<0.05) increase in the level of creatinine and blood urea nitrogen (BUN) at doses of 500 and 750 mg/kg BW, but the increased level of creatinine at 500 mg/kg BW did not reach the limit level (0.8 mg/dL). However, histopathological results showed no alteration in renal tissues. These results indicate that leaf extract of A. rugata may be safely used as a medicinal herb and recommended at doses lower than 250 mg/kg..
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