Alkaloids from Marrubium vulgare L.: Antioxidant and Anti-Inflammatory Activities as a Function of Extraction Methods http://www.doi.org/10.26538/tjnpr/v7i7.120
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Abstract
Marrubium vulgare L, commonly known as white horehound, is a medicinal plant widely recognized for its therapeutic properties. It has been extensively studied for its bioactive compounds, including alkaloids, which possess significant antioxidant and anti-inflammatory activities. This study investigates the impact of four extraction methods (soxhlet, refluxing, maceration A, and maceration B) on the antioxidant and anti-inflammatory activities of alkaloids from Marrubium vulgare L. The qualitative analysis reveals Emetine and Cephaeline as the predominant alkaloid compounds in the plant leaf extracts. Among the methods, soxhlet and
maceration B demonstrate the highest extraction yields (9.81% and 9.57% respectively). Notably, maceration B exhibits exceptional antioxidant activity as ascorbic acid equivalent per gram of dry matter (2370.53 AAE/1gDM), while soxhlet exhibits remarkable anti-inflammatory activity (78.51% inhibition at 500 mg/kg, 180 minutes post-formol injection). These findings underscore the importance of maceration B and soxhlet methods for enhancing alkaloid extraction yield and bioactivity.
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