Click Chemistry-Based Synthesis of Novel 1,2,3-Triazole Derivatives and Cytotoxic Activity on Breast and Prostate Cancer Cell Lines

http://www.doi.org/10.26538/tjnpr/v7i7.6

Authors

  • Hamsa H. Al-hujaj Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah, Iraq
  • Faeza A. Almashal Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah, Iraq
  • Aqeel T. Kadum The General Company for the Petrochemical Industry, Basrah, Iraq
  • Mohammed K. Mohammed Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah, Iraq
  • Kawkab Ali Hussein Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah, Iraq
  • Ahmed M. Jassem Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah, Iraq

Keywords:

Prostate cancer, Click chemistry, Breast cancer, Anticancer, 1,2,3-triazole

Abstract

Breast and prostate cancers are a major cause of death each year. Most available anticancer drugs are not very effective and can cause side effects. Identifying a safe and effective alternative drug with fewer side effects for long-term anticancer therapy is therefore necessary. The present study was aimed at synthesizing 1,2,3-triazole derivatives and evaluating their activity against human breast cancer (MCF-7) and prostate cancer (PC-3) cell lines. Novel series of three 1,2,3-triazole derivatives (T1, T2, and T3 compounds) were synthesized. The compounds were produced by the Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition process. They were subsequently subjected to IR, H-NMR, and ESI-MS spectroscopic analyses. An in vitro cytotoxicity assay was conducted on each newly synthesized compound against MCF-7 and PC- 3 cells. The results showed that most of the T1, T2, and T3 test compounds exhibited significant cytotoxic action. The principal derivatives T1 and T2 are the compounds with the most promising cytotoxic activity. Furthermore, when compared to the standard 5-FU drug, the IC50 values for the compounds T1, T2, and T3 against the PC-3 cell line were 273.947, 406.303, and 314.368 M, respectively, while they were 91.476, 132.658, and 116.232 against breast cancer cells when compared to the standard drug adriamycin. The findings of this study demonstrated that the novel synthesized compounds could be used as potential anticancer drugs. 

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Published

2023-07-31

How to Cite

Al-hujaj, H. H., Almashal, F. A., Kadum, A. T., Mohammed, M. K., Hussein, K. A., & Jassem, A. M. (2023). Click Chemistry-Based Synthesis of Novel 1,2,3-Triazole Derivatives and Cytotoxic Activity on Breast and Prostate Cancer Cell Lines: http://www.doi.org/10.26538/tjnpr/v7i7.6. Tropical Journal of Natural Product Research (TJNPR), 7(7), 3306–3313. Retrieved from https://tjnpr.org/index.php/home/article/view/2216