Mercury-Induced Acute Nephrotoxicity in Rats:Treatment with Aqueous Extract of Pistacia atlantica (Desf)
doi.org/10.26538/tjnpr/v5i12.3
Keywords:
Mercury, Liver, Kidney, Redox status, Pistacia atlantica, RatAbstract
Mercury is known to accumulate in living organisms, causing serious damage. An important characteristic of mercury toxicity is the generation of free radicals. The purpose of this study is to evaluate the protective effect of the aqueous extract of Pistacia atlantica against mercury-induced oxidative stress in rats. Mercury chloride (HgCl2) was administered intraperitoneally (at 2.5 mg/kg once per week), and P. atlantica was given orally by gavage at a daily dose of 150 \mg/kg body weight to rats for 32 days. These results show that HgCl2 caused a significant depletion of the glutathione level and the enzymatic activity of the antioxidant system catalase (CAT), Glutathion peroxidase (GPx,), Glutathion S transferase (GST) at the renal level. These changes were associated with increased lipid peroxidation expressed by a high level of renal Malondialdehyde (MDA) and hydroperoxides (LOOH). However, supplementation with the aqueous extract of Pistacia atlantica modified the toxic effects of mercury by reducing lipid peroxidation. These findings may indicate an antioxidant and protective effect of this plant's extract against mercury's harmful effect.
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