Evaluation of Pain-Relieving Effect of The Herbal Remedy “Hoang Ky Que Chi Ngu Vat Thang” in Animal Model
http://www.doi.org/10.26538/tjnpr/v7i6.14
Keywords:
mice, traditional medicine, Hoang ky que chi ngu vat thang, Pain reliefAbstract
Musculoskeletal pain is a significant burden on individuals and society. "Hoang ky que chi ngu vat thang" is a traditional Vietnamese remedy used to treat this condition, but there is a lack of clinical evidence regarding its pain relief mechanism. The objective of this study is to evaluate the analgesic effect of "Hoang ky que chi ngu vat thang" in Swiss mice. The central analgesic effect was evaluated using the hot plate latency test, and the peripheral analgesic effect was evaluated using the writhing test with acetic acid. The results of this study showed that statistically significant differences were observed between the treated groups with "Hoang ky que chi ngu vat
thang" and the standard group 1 and control group (p < 0.05). Furthermore, the number of writhing pain during 25 minutes after acetic acid injection in both groups with dose 14.112 and dose 28.224 was significantly lower (p < 0.01) compared to the reference group (Lysine acetylsalicylate). Conclusively, oral doses of 14.112 g/kg and 28.224 g/kg of "Hoang ky que chi ngu vat thang"
have a good analgesic effect via both central and peripheral analgesic mechanisms.
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