Biochemical and Hepatoprotective Effects of Gangronema latifolium Extract on Alloxan-Induced Diabetic Rats
doi.org/10.26538/tjnpr/v6i1.23
Keywords:
Gongronema latifolium, Diabetes, Wistar rats, Alloxan, LiverAbstract
Diabetes mellitus is a chronic metabolic disease associated with hyperglycemia, dyslipidemia, and hepatocellular damage. Gongronema latifolium has been widely explored in ethnomedicine for the treatment and management of various disorders. The biochemical, hepatoprotective, and histological effects of aqueous-ethanolic leaf extract of G. latifolium (Family: Asclepiadaceae) in alloxan-induced diabetic rats were investigated in this study. Thirty (30) juvenile male Wistar rats were placed into six groups, each with five rats: Normal rats made up Group 1, while diabetic rats in Groups 2–4 were given 200, 400, and 800 mg/kg body weight of aqueous ethanolic leaf extract, respectively; diabetic rats in Group 5 were given a standard anti-diabetic drug (0.2 mg/kg glibenclamide), and diabetic rats in Group 6 were left untreated. When compared to control rats, alloxan-induced diabetic rats showed a significant (p ≤ 0.05) rise in liver enzymes, low density lipoprotein (LDL), total cholesterol (TC), triglycerides (TG), and fasting blood glucose (FBG), but a significant (p ≤ 0.05) decrease in high density lipoprotein(HDL). The alterations in the following parameters were returned to normal levels when the diabetic rats were administered G. latifolium extract. At the end of the experimental period, the rats were sacrificed, and each experimental group's liver tissues were removed and used for histopathological examinations. When compared to the normal control and treatment groups,which had normal liver histological features, the diabetes group's histology showed cytoplasmic deterioration. The results indicate that G. latifolium may serve as a remedy for the management of diabetes.
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