Evaluation of Honey-Based Pharmaceutical Preparations for the Management of Diabetic Wounds
doi.org/10.26538/tjnpr/v6i1.18
Keywords:
Aloe vera, Antimicrobial activity, Chlorhexidine, Diabetic wounds, Hone, SyrupAbstract
Management of Diabetic wounds is a financial burden globally. Investigations into cheaper and alternative dressings to manage these wounds especially in developing countries like Nigeria is crucial. Honey was used to treat wounds since ancient times till nowadays. This present study aimed at preparing honey with other actives and assay its antimicrobial properties and wound healing activity; in-vitro and in-vivo, also to compare its effectiveness against sugar syrup. Raw honey obtained was processed and characterized. Eight formulations F1 to F4 containing 66.7% syrup and either chlorhexidine or aloe-vera or both and F5 to F8 containing 75% Honey with or without the other actives were prepared, characterized, and investigated on their antimicrobial and wound healing properties in a diabetic rat model. The honey sample was found to be of good quality from the physicochemical and microscopical analysis carried out. Formulation F8 containing Honey 75%, Aloe vera 1%, and chlorhexidine 0.02% showed the highest antimicrobial activity with none of the formulations showing any significant activity against the fungal isolate. The wound healing effects of the formulations were comparative but honey containing formulations showed better diabetic wound healing activity with formulation F8 giving total and complete healing of the diabetic wound. Honey in conjunction with Aloe vera and chlorhexidine has better antibacterial and wound healing activity than syrup, according to this study, and could be utilized as a safe and effective natural diabetic wound healing treatment.
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