Annona muricata Leaf Extract Modulates Chloramphenicol-Induced Lymphoma in Female Wistar Rats http://www.doi.org/10.26538/tjnpr/v7i5.31
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Abstract
Chloramphenicol, an antibiotic used to treat bacterial infections, is also implicated in several
conditions, including aplastic anaemia that progresses to leukaemia. The modulatory potential of
leaf extract of Annona muricata on chloramphenicol-induced lymphoma (CIL) in female Wistar
rats was investigated. Forty-eight adult female rats with an average weight of 186 g were
randomized into 6 groups of 8 rats each. Rats in Group 1 served as the positive control. Each rat
in Groups 2-6 was orally administered with 250 mg/kg bodyweight chloramphenicol once daily
for 28 days. The rats were given access to basal diet and water. After 28 days, blood-film analyses
were carried out from each of the groups. The presence of blast and lymphoproliferative cells in
Groups 2-6 confirmed CIL. Groups 1 and 2 rats received distilled water, while Groups 3-6
received 500, 1000, 1500, and 2000 mg/kg, respectively, of A. muricata for another 28 days. The
animals were anesthetized, blood was collected from the retro-orbital venous plexus for
determination of haematological indices; oxidative stress markers; lactate dehydrogenase,
superoxide dismutase, catalase, glutathione, malondialdehyde, cardiac markers; Troponin-1,
myoglobin, cancer indices; C-reactive protein, carcinoembryonic antigen, Alpha-fetoprotein.
There was significant (p<0.05) amelioration of impaired haematological indices in the treated
groups when compared to Group 2. Troponin-I and myoglobin were significantly (p<0.05)
lowered in the treated groups when compared to Group 2. Oxidative stress markers and cancer
indices were increased in Group 2, but significantly (p<0.05) ameliorated in Groups 3-6.
Therefore, A. muricata has the potential to modulate adverse effects of CIL.
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