Sub-Acute Toxicity Profile of Aqueous Leaf Extract of Pavetta crassipes (K. Schum) in Rats http://www.doi.org/10.26538/tjnpr/v7i5.25
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Abstract
Pavetta crassipes is a plant with many ethnomedicinal uses but has limited published data on its safety. The aim of the study was to evaluate the subacute oral toxicity of aqueous leaf extract of P. crassipes in Wister rats. Thirty-six Wister male rats were randomly divided into 6 groups of six rats each. They were treated with; 1 mL/kg distilled water (negative control group), aqueous leaf extract of P. crassipes (125, 250 and 500 mg/kg test groups respectively), 10 mg/kg furosemide (positive control group 1), and 10 mg/kg lisinopril (positive control group 2) daily for 28 days. Weekly animal weight, food consumption, water intake, fecal/urine outputs, organ to
body weight ratio, hematological, biochemical and histological assessment of organs were used to evaluating toxicity. There was no significant difference between all the groups in body weight, food/water intake, fecal output, plasma sodium, potassium, chloride, calcium and biochemical markers of liver and kidney function (p›0.05). However, P. crassipes leaf extract significantly increases the urine excretion, high density lipoprotein (HDL) and endogenous antioxidant (p‹0.05) with a decrease in total cholesterol, triglyceride and low density lipoprotein (p‹0.05) in rats. Aqueous leaves extract of P. crassipes is relatively safe because the biochemical parameters and organs assayed were within the values for distilled water treated rats.
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