Effects of Plant Part Substitution in a Thai Traditional Recipe on α-Glucosidase Inhibition http://www.doi.org/10.26538/tjnpr/v7i5.12

Main Article Content

Pattraporn Sabuhom
Phetpawi Subin
Prathan Luecha
Somsak Nualkaew
Natsajee Nualkaew

Abstract

A Thai polyherbal antipyretic remedy, TPDM6315, consists of herbal constituents that possess anti-diabetic properties. It contains 15 plants, of which the roots of 3 crude drugs, Solanum indicum (R-Si), Solanum trilobatum (R-St), and Gymnopetalum integrifolium (R-Gi), are insufficiently supplied in the herbal market, while their stems or aerial parts (S-Si, S-St, and S-Gi, respectively), are available. This study aimed to determine the anti-diabetic properties of the recipe extract and evaluate the possible substitution of those crude drugs. The chemical properties and the in vitro -glucosidase inhibition were investigated in the single herbal ingredient and the recipe extracts. The results indicated that TPDM6315 extracts inhibited -glucosidase as a mixedtype inhibitor. The high-performance liquid chromatography (HPLC) profiles between the root and stem of those herbs were different but highly similar to the recipe extracts. The substituted recipe (S-Et, containing S-Si, S-St, and S-Gi) exhibited higher potency on α-glucosidase inhibition than the original recipe (R-Et, containing R-Si, R-St, and R-Gi) (P<0.01). This study revealed substitution in TPDM6315 was possible for α-glucosidase inhibitory properties since it only partially affected the overall chemical profile while raising the α-glucosidase inhibitory activity of the recipe extracts. 

Article Details

How to Cite
Sabuhom, P., Subin, P., Luecha, P., Nualkaew, S., & Nualkaew, N. (2023). Effects of Plant Part Substitution in a Thai Traditional Recipe on α-Glucosidase Inhibition: http://www.doi.org/10.26538/tjnpr/v7i5.12. Tropical Journal of Natural Product Research (TJNPR), 7(5), 2919–2925. Retrieved from https://tjnpr.org/index.php/home/article/view/1979
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