Effects of Plant Part Substitution in a Thai Traditional Recipe on α-Glucosidase Inhibition http://www.doi.org/10.26538/tjnpr/v7i5.12
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Abstract
A Thai polyherbal antipyretic remedy, TPDM6315, consists of herbal constituents that possess anti-diabetic properties. It contains 15 plants, of which the roots of 3 crude drugs, Solanum indicum (R-Si), Solanum trilobatum (R-St), and Gymnopetalum integrifolium (R-Gi), are insufficiently supplied in the herbal market, while their stems or aerial parts (S-Si, S-St, and S-Gi, respectively), are available. This study aimed to determine the anti-diabetic properties of the recipe extract and evaluate the possible substitution of those crude drugs. The chemical properties and the in vitro -glucosidase inhibition were investigated in the single herbal ingredient and the recipe extracts. The results indicated that TPDM6315 extracts inhibited -glucosidase as a mixedtype inhibitor. The high-performance liquid chromatography (HPLC) profiles between the root and stem of those herbs were different but highly similar to the recipe extracts. The substituted recipe (S-Et, containing S-Si, S-St, and S-Gi) exhibited higher potency on α-glucosidase inhibition than the original recipe (R-Et, containing R-Si, R-St, and R-Gi) (P<0.01). This study revealed substitution in TPDM6315 was possible for α-glucosidase inhibitory properties since it only partially affected the overall chemical profile while raising the α-glucosidase inhibitory activity of the recipe extracts.
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References
Prapaspong B. Paet-Ta-Ya-Saat-Song-Kror: Medical wisdom and literary heritage of the nation. Bangkok: Thai Language Institute, Department of Academic Affairs, Ministry of Education; 1999. (in Thai)
Tshabalala T, Ndhlala AR, Ncube B, Abdelgadir HA, Van Staden J. Potential substitution of the root with the leaf in the use of Moringa oleifera for antimicrobial, antidiabetic and antioxidant properties. S Afr J Bot. 2020; 129: 106-112.
Jena AK, Karan M, Vasisht K. Plant parts substitution based approach as a viable conservation strategy for medicinal plants: a case study of Premna latifolia Roxb. J Ayurveda Integr Med. 2017; 8(2): 68-72.
Dirir AM, Daou M, Yousef AF, Yousef LF. A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes. Phytochem Rev. 2022; 21(4): 1049-1079.
Oboh G, Ogunsuyi OB, Ogunbadejo MD, Adefegha SA. Influence of gallic acid on α-amylase and α-glucosidase inhibitory properties of acarbose. J Food Drug Anal. 2016; 24(3): 627–634.
Pompimon W, Wattananon S, Udomputtimekakul P, Baison W, Sombutsiri P, Chuajedton A, Wingwon B. HPLC determination of the gallic acid and chebulinic acid contents of Phyllanthus emblica Linn., Terminalia bellirica Roxb., Terminalia chebula Retz. and Triphala products from Chae
Son district, Lampang, Thailand. Am J Food Technol. 2020; 8(3): 87-98.
Gao H, Huang YN, Xu PY, Kawabata J. Inhibitory effect on α-glucosidase by the fruits of Terminalia chebula Retz. Food Chem. 2007; 105(2): 628–634.
Gao H, Huang YN, Gao B, Kawabata J. Chebulagic acid is a potent α-glucosidase inhibitor. Biosci Biotechnol Biochem. 2008; 72(2): 601–603.
Tran HHT, Nguyen MC, Le HT, Nguyen TL, Pham TB, Chau VM, Nguyen HN, Nguyen TD. Inhibitors of α - glucosidase and α -amylase from Cyperus rotundus. Pharm Biol. 2014; 52(1): 74–77.
Singleton VL, Orthofer R, Lamuela-Raventós RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. Meth Enzymol. 1999; 299: 152–178.
Timotius KH, Simamora A, Santoso AW. Chemical characteristics and in vitro antidiabetic and antioxidant activities of Premna serratifolia L. leaf infusion and decoction. Pharmacogn J. 2018; 10: 1114-1118.
Simamora A, Paramita L, Azreen N, Santoso AW, Timotius KH. In vitro antidiabetic and antioxidant activities of aqueous extract from the leaf and fruit of Psidium guajava L. Indones Biomed J. 2018; 10(2): 156–164.
Adisakwattana S, Charoenlertkul P, Yibchok-anun S. α- Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose. J Enzyme Inhib Med Chem. 2009; 24(1):65–69.
Nigam M, Mishra AP, Adhikari‐Devkota A, Dirar AI, Hassan MM, Adhikari A, Belwal T, Devkota HP. Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities. Phytother Res. 2020; 34(10):2518–2533.
Singh A, Bajpai V, Kumar S, Kumar B, Srivastava M, Rameshkumar KB. Comparative profiling of phenolic compounds from different plant parts of six Terminalia species by liquid chromatography–tandem mass spectrometry with chemometric analysis. Ind Crops Prod.2016; 87:236–246.
Rose K, Wan C, Thomas A, Seeram NP, Ma H. Phenolic compounds isolated and identified from amla (Phyllanthus emblica) juice powder and their antioxidant and neuroprotective activities. Nat Prod Commun. 2018; 13(10) :1309–1311.
Yang B, Liu P. Composition and biological activities of hydrolyzable tannins of fruits of Phyllanthus emblica. J Agric Food Chem. 2014; 62(3): 529–541.
Zhang YJ, Abe T, Tanaka T, Yang CR, Kouno I. Phyllanemblinins A−F, new ellagitannins from Phyllanthus emblica. J Nat Prod. 2001; 64(12): 1527–1532.
Han HS, Jeon H, Kang SC. Phellopterin isolated from Angelica dahurica reduces blood glucose level in diabetic mice. Heliyon. 2018; 4(3): e00577.
Park EY, Kim EH, Kim CY, Kim MH, Choung JS, Oh YS, Moon HS, Jun HS. Angelica dahurica extracts improve glucose tolerance through the activation of GPR119. PLoS ONE. 2016;11(7):e0158796.
Li Y, Tran VH, Duke CC, Roufogalis BD. Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes. Planta Med. 2012; 78(14):1549–1555.
Jung MY, Lee MK, Park HJ, Oh EB, Shin JY, Park JS, Jung SY, Oh JH, Choi DS. Heat-induced conversion of gingerols to shogaols in ginger as affected by heat type (dry or moist heat), sample type (fresh or dried), temperature and time. Food Sci Biotechnol. 2018; 27(3):687–693.
Lokman FE, Gu HF, Wan Mohamud WN, Yusoff MM, Chia KL, Ostenson CG. Antidiabetic effect of oral borapetol b compound, isolated from the plant Tinospora crispa, by stimulating insulin release. Evid Based Complement Altern Med. 2013; 2013: 727602.
Lam SH, Ruan CT, Hsieh PH, Su MJ, Lee SS. Hypoglycemic diterpenoids from Tinospora crispa. J Nat Prod. 2012; 75(2): 153–159.
Sah JN, Varshney VK. Chemical constituents of Picrorhiza genus: a review. Am J Essent Oil Nat Prod 2013; 1(2):22-37.
Badhani B, Sharma N, Kakkar R. Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications. RSC Adv. 2015; 5(35):27540–27557.
Kashtoh H, Baek KH. Recent updates on phytoconstituent alpha-glucosidase inhibitors: an approach towards the treatment of type two diabetes. Plants 2022; 11(20): 2722.
Zhang H, Wang G, Beta T, Dong J. Inhibitory properties of aqueous ethanol extracts of propolis on alpha-glucosidase. Evid Based Complement Altern Med. 2015; 2015: 587383.
Sahere R, Soheila M, Homaei A, Moein MR. Kinetics of α- glucosidase inhibition by different fractions of three species of Labiatae extracts: a new diabetes treatment model. Pharm Biol. 2017; 55(1): 1483–1488.