Assessment of Potential Carcinogens in Some Fast Foods Sold in A Nigerian University Campus doi.org/10.26538/tjnpr/v6i1.10
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Abstract
The subject of cancer is one that has become widely recognised in the world, with several factors contributing to its onset in a person. One of the most prominent factors associated with the development of cancer is the presence of carcinogenic contaminants in consumed foods. This study assayed for two contaminants (potassium bromate and acrylamide) recognised as potential carcinogens by the International Agency for Research on Cancer (IARC) in selected fast foods consumed within a Nigerian University campus. Samples of fifteen different bread and flour products were analysed for potassium bromate using a standard spectroscopic method, and acrylamide analysis by HPLC was carried out on four different fried potato samples. Potassium bromate was present in 67% of the samples analysed in amounts ranging from 2.677±0.25 mg/kg to 7.839±0.36 mg/kg. Acrylamide was present in amounts ranging from 1.92 µg/kg to 23.67 µg/kg in 50% of the potato samples analysed. The tolerable daily acrylamide intake is estimated at 2.6 µg/kg body weight per day. Based on the result obtained, some of the bread and fried potatoes sold within a Nigerian University campus contained potassium bromate and acrylamide, compounds known as potential carcinogens.
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Baba AI and Câtoi C. Comparative oncology. Bucharest: Publishing House of the Romanian Academy. [Online] 2007. [cited 2019 Aug 19]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9552/
Blackadar CB. Historical review of the causes of cancer. World J Clin Oncol. 2016; 7(1):54.
Weisburger JH, Barnes WS, Czerniak R. Mutagens and carcinogens in food. In diet, nutrition, and cancer: a critical evaluation. Florida: CRC Press; 2018; 115-134p.
Morounke SG, Ayorinde JB, Benedict AO, Adedayo FF, Adewale FO, Oluwadamilare I, Sokunle SS, Benjamin A. Epidemiology and incidence of common cancers in Nigeria. J Cancer Biol Res. 2017; 5(3):1105-1127.
World Health Organization. Cancer country profile 2020. [Online] 2020. [cited 2020 August 20]. Available from: https://www.iccpportal.org/system/files/plans/NGA_2020.pdf.
Khan MR, Naushad M, Alothman ZA. Presence of heterocyclic amine carcinogens in home-cooked and fastfood camel meat burgers commonly consumed in Saudi Arabia. Sci Rep. 2017; 7(1):1-7.
Hartwig A, Arand M, Epe B, Guth S, Jahnke G, Lampen A, Martus HJ, Monien B, Rietjens IM, Schmitz-Spanke S, Schriever-Schwemmer G. Mode of action-based risk assessment of genotoxic carcinogens. Arch Toxicol. 2020; 94(6): 1787-877.
Rifai L and Saleh FA. A review on acrylamide in food: occurrence, toxicity, and mitigation strategies. Int J Toxicol. 2020; 39(2):93-102.
Genovese J, Tappi S, Luo W, Tylewicz U, Marzocchi S, Marziali S, Romani S, Ragni L, Rocculi P. Important factors to consider for acrylamide mitigation in potato crisps using pulsed electric fields. Innov. Food Sci Emerg Technol. 2019; 55(2019):18-26.
Yang Y, Achaerandio I, Pujolà M. Influence of the frying process and potato cultivar on acrylamide formation in French fries. Food Contr. 2016; 62(2016):216-223.
de Conti A, Tryndyak V, VonTungeln LS, Churchwell MI, Beland FA, Antunes AM, Pogribny IP. Genotoxic and epigenotoxic alterations in the lung and liver of mice induced by acrylamide: a 28 day drinking water study.Chem Res Toxicol. 2019; 32(5):869-877.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 60: Some Industrial Chemicals. [Online] 1994. [cited 2019 July 3]. Available from: https://monographs.iarc.fr/wpcontent/uploads/2018/06/mono60-16
U.S. National Toxicology Program. Report on Carcinogens: Acrylamide. 14th edition: Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. [Online] 2016. [cited 2019 July 3]. Available from: https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylamide
International Agency for Research on Cancer. Potassium bromate. In: International Agency for Research on CancerSummaries & Evaluations. Geneva: IPCS INCHEM; 1999. 481 p. Available from http://www.inchem.org/documents/iarc/vol73/73-17.htmL
National Agency for Food, Drug Administration and Control (NAFDAC). Consumer Safety Bulletin. (Vol. 2). Abuja: National Agency for Food and Drug Administration and Control; 2003.
Emeje MO, Ofoefule SI, Nnaji AC, Ofoefule AU, Brown SA. Assessment of bread safety in Nigeria: Quantitative determination of potassium bromate and lead. Afr J Food Sci. 2010; 4(6):394-397.
Emeje OM, Ifiora BI, Ezenyi CI, Ofoefule SI. Assessment of bread safety in Nigeria: one decade after the ban on the use of potassium bromate. J Food Proc Tech. 2015; 6(1):409
Airaodion AI, Ewa O, Ogbuagu EO, Ogbuagu U, Agunbiade AP, Oloruntoba AP. Evaluation of potassium bromate in bread in Ibadan metropolis: Fifteen years after ban in Nigeria. Asian Food Sci J. 2019; 7(4):1-7.
Achukwu PU and Omorodion RI. Formulation of rapid method for detection and estimation of bromate in serum and confectionaries consumed in Enugu, Nigeria. Res JFood Nutr. 2018; 2(2):62-70.
Wang H, Feng F, Guo Y, Shuang S, Choi MM. HPLC-UV quantitative analysis of acrylamide in baked and deep-fried Chinese foods. J Food Composit Anal. 2013; 31(1):7-11.
Rosen C, Sun N, Olsen N, Thornton M, Pavek M, Knowles L, Knowles NR. Impact of agronomic and storage practices on acrylamide in processed potatoes. Am J Potato Res. 2018; 95(4):319-327.
Manière I, Godard T, Doerge DR, Churchwell MI, Guffroy M, Laurentie M, Poul JM. DNA damage and DNA adduct formation in rat tissues following oral administration of acrylamide. Mutat Res Genet Toxicol Environ Mutagen. 2005; 580(1-2):119-129.
Mucci LA, Dickman PW, Steineck G, Adami HO, Augustsson K. Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br J Cancer. 2003; 88(1):84-89.
Pelucchi C, Franceschi S, Levi F, Trichopoulos D, Bosetti C, Negri E, La Vecchia C. Fried potatoes and human cancer. Int J Cancer. 2003; 105(4):558-560.
Hogervorst JG, van den Brandt PA, Godschalk RW, van Schooten FJ, Schouten LJ. The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk. Sci Rep. 2016; 6(1):1-10.
Kumar J, Das S, Teoh SL. Dietary acrylamide and the risks of developing cancer: Facts to ponder. Front Nutr. 2018; 5(2018):14.
Tardiff RG, Gargas ML, Kirman CR, Carson ML, Sweeney LM. Estimation of safe dietary intake levels of acrylamide for humans. Food Chem Toxicol. 2010; 48(2): 658-667.
Zamani E, Shokrzadeh M, Fallah M, Shaki F. A review of acrylamide toxicity and its mechanism. Pharm Biomed Res. 2017; 3(1):1-7.