Arginase II Inhibitory Activity of Phenolic Compounds from Caesalpinia sappan L.
http://www.doi.org/10.26538/tjnpr/v7i4.12
Keywords:
C57BL/6 mice, arginase, phenolic, Leguminosae, Caesalpinia sappanAbstract
Inhibition of arginase from natural compounds has been proposed as a therapeutic approach for the treatment of cardiovascular diseases. Therefore, this study aims to evaluate the arginase inhibitory activity of isolated compounds. Based on bioactivity-guided fractionation, the ethyl acetate fraction was further subjected to column chromatography to obtain seven compounds (1−7). The chemical structures of the isolated compounds were determined by analyzing NMR spectral data and referring to data from the literature. The arginase II inhibitory activity of compounds 1–7 were investigated in vitro using an enzyme solution prepared from the kidney of anesthetized C57BL/6 mice. Compounds 1, 2, and 7 potentially inhibit arginase II activity, with IC50 values ranging from 8.1 to 14.2 μM, whereas the remaining compounds were inactive. This study is the first to assess compounds isolated from C. sappan heartwood with regard to their arginase inhibitory activity.
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