An Overview of Pomegranate Peel: A Waste Treasure for Antiviral Activity doi.org/10.26538/tjnpr/v6i1.3
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Abstract
Agricultural waste has always been a global problem that causes environmental pollution, and thanks to the efforts of scientists, this agricultural waste has become not a neglected product, but rather a source of many effective chemical compounds that have industrial, pharmaceutical and food applications. Viral disease therapy has attracted a great deal of scientific interest worldwide. Therefore, the pace of research is increasing for effective and safe treatment. The potential inhibitory activity of pomegranate peel extract polyphenols against virus for effective viral disease therapy has attracted a great deal of scientific interest. The aim of this review was to present an overview of the pomegranate peel effects on viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Influenza virus, Norovirus, Adenovirus, Herpes simplex virus, Coronavirus disease (COVID-19). Pomegranate is consumed as fresh fruit and juice for its reported health benefits as antioxidant, antidiabetic, hypolipidemic, antibacterial, anti-inflammatory, antiviral, anticarcinogenic activities, and improves cardiovascular as well as oral health. The health benefits of pomegranate have been attributed to its wide range of phytochemicals, which are predominantly polyphenols, ellagitannins, anthocyanins, and other polyphenols. Instead of the pomegranate peel being a neglected product, it is considered as a promising antiviral agent which also offers other health benefits without side effects.
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References
Al-Zoreky NS. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. Int J Food Microbiol. 2009; 134(3): 244-248.
Kaderides K, Goula AM, Adamopoulos KG. A process for turning pomegranate peels into a valuable food ingredient using ultrasound-assisted extraction and encapsulation. Innov Food Sci Emerg Technol. 2015; 31:204-215.
Kyriakidou A, Makris DP, Lazaridou A, Biliaderis CG, Mourtzinos I. Physical properties of chitosan films containing pomegranate peel extracts obtained by deep eutectic solvents. Foods. 2021;10(6):1262.
Mirjalili S. A review on biochemical constituents and medicinal properties of pomegranate (Punica granatum L.). J Med Plants. 2015; 14(56):1-22.
Akhtar S, Ismail T, Fraternale D, Sestili P. Pomegranate peel and peel extracts: Chemistry and food features. Food Chem. 2015; 174:417-425.
Diamanti AC, Igoumenidis PE, Mourtzinos I, Yannakopoulou K, Karathanos VT. Green extraction of polyphenols from whole pomegranate fruit using cyclodextrins. Food Chem. 2017; 214:61-66.
Masci A, Coccia A, Lendaro E, Mosca L, Paolicelli P, Cesa S. Evaluation of different extraction methods from pomegranate whole fruit or peels and the antioxidant and antiproliferative activity of the polyphenolic fraction. Food Chem. 2016; 202:59-69.
Salgado MJ, Ferreira BTR, Biazotto, FO, Dias, CTS. Increased antioxidant content in juice enriched with dried extract of pomegranate (Punica granatum) peel. Plant Foods Hum Nutr. 2012; 67(1):39-43.
Melgarejo P, Salazar DM, Artés F. Organic acids and sugars composition of harvested pomegranate fruits. Eur Food Res Technol. 2000; 211:185-190.
Spilmont M, Léotoing L, Davicco MJ, Lebecque P, MiotNoirault E, Pilet P, Rios L, Wittrant Y, Coxam V. Pomegranate peel extract prevents bone loss in a preclinical model of osteoporosis and stimulates osteoblastic differentiation in vitro. Nutrients. 2015; 7(11):9265-9284.
Plumb GW, de Pascual-Teresa S, Santos-Buelga C, RivasGonzalo JC, Williamson G. Antioxidant properties of gallocatechin and prodelphinidins from pomegranate peel. Redox Rep. 2002; 7(1):41-46.
Lansky EP and Newman RA. Punica granatum(pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 2007; 109(2):177-206.
Negi PS and Jayaprakasha GK. Antioxidant and antibacterial activities of Punica granatum peel extracts. J Food Sci. 2003; 68(4):1473-1477.
Suručić R, Travar M, Petković M, Tubić B, Stojiljković MP, Grabež M, Šavikin K, Zdunić G, Škrbić R. Pomegranate peel extract polyphenols attenuate the SARSCoV-2 S-glycoprotein binding ability to ACE2 Receptor: In silico and in vitro studies. Bioorg Chem. 2021; 114:105145.
Šavikin K, Živković J, Alimpić A, Zdunić G, Janković T, Duletić-Lauˇsević S, Menković N. Activity guided fractionation of pomegranate extract and its antioxidant, antidiabetic and antineurodegenerative properties. Ind Crops Prod. 2018; 13(1):142-149.
Gozlekci S, Saracoglu O, Onursal E, Ozgen M. Total phenolic distribution of juice, peel, and seed extracts of four pomegranate cultivars. Pharmacogn Mag. 2011; 7(26):161-164.
Corao GMD. Antiviral effects of ingredients in the fruit rind of Punica granatum L. School of pharmacy and biomolecular sciences. PhD Thesis, University of Brighton. 2001.
Neurath AR, Strick N, Li YY, Debnath AK. Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. Ann NY Acad Sci. 2005; 1056:311-327.
Centers for Disease Control and Prevention (CDC): Norovirus. National Center for Immunization and Respiratory Diseases (NCIRD). (cited December 2021). Available from: https://www.cdc.gov/ncird/index.html.
Bartsch SM, O'Shea KJ, Lee BY. The clinical and economic burden of norovirus gastroenteritis in the United States. J Infect Dis. 2020; 222(11):1910-1919.
Bialonska D, Kasimsetty SG, Schrader KK, Ferreira D. The effect of pomegranate (Punica granatum L.) by products and ellagitannins on the growth of human gut bacteria. J Agric Food Chem. 2009; 57(18):8344-8349.
Ismail T, Akhtar S, Riaz M, Ismail A. Effect of pomegranate peel supplementation on nutritional, organoleptic and stability properties of cookies. Int J Food Sci Nutr. 2014; 65(6):661-666.
Nozohour Y, Golmohammadi R, Mirnejad R, Fartashvand M. Antibacterial activity of pomegranate (Punica granatumL.) seed and peel alcoholic extracts on Staphylococcus aureus and Pseudomonas aeruginosa isolated from health centres. J Appl Biotechnol Rep. 2018; 5(1):32-36.
Moradi MT, Karimi A, Rafieian-kopaei M, RabieiFaradonbeh M, Momtaz H. Pomegranate peel extract inhibits internalization and replication of the influenza virus: an in vitro study. Avicenna J Phytomed. 2020; 10(2):143-151.
Živković I, Šavikin K, Živković J, Zdunić G, Janković T, Lazić D, Radin D. Antiviral effects of pomegranate peel extracts on human Norovirus in food models and simulated gastrointestinal fluids. Plant Foods Hum Nutr. 2021; 76(2):203-209.
Li D, Baert L, Uyttendaele M. Inactivation of food-borne viruses using natural biochemical substances. Food Microbiol. 2013; 35(1):1-9.
Nair M, Saxena A, Kaur C. Effect of chitosan and alginatebased coatings enriched with pomegranate peel extract to extend the postharvest quality of guava (Psidium guajavaL.). Food Chem. 2018; 240:245-252.
Karimi A, Moradi M, Rabiei M, Alidadi S. In vitro antiadenoviral activities of ethanol extract, fractions, and main phenolic compounds of pomegranate (Punica granatum L.) peel. Antivir Chem Chemother. 2020; 28:1-6.
Ghebremedhin B. Human adenovirus: viral pathogen with increasing importance. Eur J Microbiol Immunol. 2014; 4(1):26-33.
Moradi M, Karimi A, Shahrani M, Hashemi L, GhaffariGoosheh M. 2019. Anti-influenza virus activity and phenolic content of pomegranate (Punica granatum L.) peel extract and fractions. Avicenna J Med Biotech. 2019; 11(4):285-291.
Hayden FG. Respiratory viral threats. Curr Opin Infect Dis. 2006; 19(2):169-178.
Houston DMJ, Bugert JJ, Denyer SP, Heard CM. Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co- administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV.
PLoS ONE. 2017; 12(6):e0179291.
Koelle DM and Corey L. Herpes simplex: insights on pathogenesis and possible vaccines. Annu Rev Med. 2008; 59:381-95.
Villarreal EC. Current and potential therapies for the treatment of herpes-virus infections. Prog Drug Res. 2003; 60:263-307.
Elion GB. Acyclovir: discovery, mechanism of action, and selectivity. J Med Virol. 1993; Suppl 1:2-6.
Hill C, McKinney E, Lowndes CM, Munro H, Murphy G, Parry JV, Gill, ON. Epidemiology of herpes simplex virus types 2 and 1 amongst men who have sex with men attending sexual health clinics in England and Wales: implications for HIV prevention and management. Euro
Surveill. 2009; 14(47):19418.
Moradi M, Karimi A, Alidadi S, Gholami-Arjenaki M. In vitro anti-herpes simplex type-1 activity, antioxidant potential and total phenolic compounds of pomegranate (Punica granatum L.) peel extract. J Chem Pharm Res. 2015; 7(8):82-88.
Johns Hopkins University, national public health agencies, 13 Dec., 2021. https://www.bbc.com/news/world-51235105.
Tito A, Colantuono A, Pirone L, Pedone E, Intartaglia D, Giamundo G, Conte I, Vitaglione P, Apone F. Pomegranate peel extract as an inhibitor of SARS-CoV-2 spike binding to human ACE2 receptor (in vitro): A promising source of novel antiviral drugs. Front Chem. 2021; 9:638187.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8):727–733.
Reddy MK, Gupta SK, Jacob MR, Khan SI, Ferreira D. Antioxidant, antimalarial and antimicrobial activities of tannin-rich fractions, ellagitannins and phenolic acids from Punica granatum L. Planta Med. 2007; 73(5):461-467.
Viuda-Martos M, Fernández-López J, Pérez-Álvarez J. Pomegranate and its many functional components as related to human health: a review. Compr Rev Food Sci Food Saf. 2010; 9(6):635-654.
Lenaerts L, De Clercq E, Naesens L. Clinical features and treatment of adenovirus infections. Rev Med Virol. 2008; 18(6):357-374.
Howell AB and D’Souza DH. The pomegranate: effects on bacteria and viruses that influence human health. EvidBased Compl Altern Med. 2013; 2013:606212.
Moradi MT, Karimi A, Shahrani M, Hashemi L, GhaffariGoosheh MS. Anti-influenza virus activity and phenolic content of pomegranate (Punica granatum L.) peel extract and fractions. Avicenna J Med Biotechnol. 2019; 11(4):285-291.
Khaerunnisa S, Kurniawan H, Awaluddin R, Suhartati S, Soetjipto S. Potential inhibitor of COVID-19 main protease (Mpro) from several medicinal plant compounds by molecular docking study. Preprints 2020; 2020030226.
Adem S, Eyupoglu V, Sarfraz I, Rasul A, Ali M. Identification of potent COVID-19 main protease (Mpro) inhibitors from natural polyphenols: an in-silico strategy unveils a hope against CORONA. Preprints 2020; 2020030333.2020.
Bhatia S, Giri S, Lal AF, Singh S. Identification of potential inhibitors of dietary polyphenols for SARS-CoV-2 M protease: an in-silico study. Trop Pub Health. 2020; 1(1):21-29.