Biogenic Silver Nanoparticles from two Species of Malvaceae: Synthesis, Antimalarial, Antitrypanosomal, Antimicrobial Properties and their Potential towards HeLa Cell Line: http://www.doi.org/10.26538/tjnpr/v7i3.26

Ogunmola Oluranti; Larayetan Rotimi; Ayeni Gideon; Abioye Oluwatayo; Majolagbe Olusola; Taofik Adedosu

Authors

Ogunmola Oluranti Department of |Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria
Larayetan Rotimi Department of pure and Industrial Chemistry, Kogi State University, Kogi State, Anyigba, Nigeria
Ayeni Gideon Department of Biochemistry, Kogi State University, Kogi State, PMB 1008, Anyigba, Nigeria
Abioye Oluwatayo Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria
Majolagbe Olusola Department of |Pure and Applied Biology, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria
Taofik Adedosu Department of |Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria

Keywords:

IC50, antitrypanosomal activity, antimalarial activity, cytotoxicity action, AgNPs, Gossypium hirsutum (GH), Gossypium barbadense (GB)

Abstract

Both Gossypium barbadense (GB) and Gossypium hirsitum (GH) are members of the Malvaceae family and the cotton genus. In order to reduce silver nitrate, aqueous extracts of both plants were used to synthesize biogenic silver nanoparticles (AgNPs) (AgNO3). The techniques employed to describe them included X-ray diffraction, ultraviolet-visible spectroscopy, scanning electron microscopy, energy dispersive X-ray (EDX), transmission electron microscopy (TEM), and the fourier transformed infrared (FTIR) spectrophotometer. The AgNPs were found to be crystalline according to the XRD spectra, but TEM images showed that they were evenly distributed, free of aggregation, and in irregular shapes with an average size of 21 nm. Only silver, oxygen, and carbon were present in the nanoparticles, according to the SEM and EDX data. Both AgNPs have excellent antimalarial efficacy when tested in vitro with Plasmodium falciparum, with IC50 values of 1.2 and 0.96 g/mL, weak antitrypanosomal potentials, and a good track record of negligible cytotoxicity against the HeLa cell line. Both AgNPs exhibit potent antiplasmodial and antibacterial characteristics, making them intriguing candidates for use in nanomedicines and other contexts where related applications are needed. The aim of this study is to biogenically synthesize silver nanoparticles (AgNPs) using the aqueous leaf extracts of GB and GH, analyze their ability to target the HeLa cell line, and determine whether they have antimalarial and
antitrypanosomal properties.

Author Biographies

Ogunmola Oluranti, Department of |Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria

Department of Chemistry Emmanuel Alayande College of Education Oyo State, Nigeria

Larayetan Rotimi, Department of pure and Industrial Chemistry, Kogi State University, Kogi State, Anyigba, Nigeria

Department of Pure and Applied Chemistry University of Fort Hare, Alice 5700, South Africa.

Ayeni Gideon, Department of Biochemistry, Kogi State University, Kogi State, PMB 1008, Anyigba, Nigeria

Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa

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Biogenic Silver Nanoparticles from two Species of Malvaceae: Synthesis, Antimalarial, Antitrypanosomal, Antimicrobial Properties and their Potential towards HeLa Cell Line

http://www.doi.org/10.26538/tjnpr/v7i3.26

Authors

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Abstract

Author Biographies

Ogunmola Oluranti, Department of |Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria

Larayetan Rotimi, Department of pure and Industrial Chemistry, Kogi State University, Kogi State, Anyigba, Nigeria

Ayeni Gideon, Department of Biochemistry, Kogi State University, Kogi State, PMB 1008, Anyigba, Nigeria

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