Prediabetes and Endothelial Involvement among Apparently Healthy Persons http://.www.doi.org/10.26538/tjnpr/v7i2.26
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Prediabetes is a state in between non-diabetic and diabetic conditions. While it is capable of progressing to diabetes, it also holds the potential for reversal of the disease process. Timely detection of this phase is therefore necessary for the control of diabetes. Moreso, persistent hyperglycaemia drives system changes through glycation processes. Notable among these changes are vascular-related complications. This study investigated hyperglycaemic states using glycated haemoglobin among persons previously screened as non-diabetic by fasting plasma glucose. The study also estimated some markers of endothelial involvement among the studied population. This study enrolled 134 apparently healthy middle-aged health workers whose highest fasting plasma glucose level (after 3 consecutive measurements) fell below the lower limit of 6.1 mmol/L used in the classification of prediabetes. Glucose oxidase and ion exchange resin methods were used to respectively assay fasting plasma glucose and glycated haemoglobin. Plasminogen activator inhibitor type1 and soluble thrombomodulin were measured by enzyme-linked immunosorbent assay method. The study observed proportions of 28% prediabetes and 10% diabetes among the participants. Mean values of glycated haemoglobin as well as plasminogen activator type1 and soluble thrombomodulin were significantly higher (p = 0.001) in subjects with prediabetes. Significant correlations were observed between glycated haemoglobin and both markers of endothelial involvement (p = 0.006 for plasminogen activator inhibitor and p = 0.013 for soluble thrombomodulin). This study observed significant vascular involvement in prediabetes.
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Agardh A, Allebeck P, Hallqvist J, Moradi T, Sidorchuk A. Type 2 diabetes incidence and socio-economic position: A systematic review and meta-analysis. Int. J. Epidemiol. 2011; 40:804-818.
Ma D, Sakai H, Wakabayashi C, Kwon JS, Lee Y, Liu S. The prevalence and risk factor control associated with noncommunicable diseases in China, Japan and Korea. J Epidemiol. 2017; 27:568-573.
Leslie RD, Palmer J, Schloot NC, Lernmark A. Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia, 2016; 59:13–20.
Narayan KM. Type 2 diabetes: Why we are winning the battle but losing the war: 2015 Kelly West Award Lecture. Diabetes Care 2016; 39:653–663.
Schwartz SS, Epstein S, Corkey BE, Grant SF, Gravin JV (3rd), Aguilar RB. The time is right for a new classification system for diabetes: rationale and implication of the-cell centric classification schema. Diabetes Care 2016; 39:179–186.
Uloko AE, Musa BM, Mansur A, Ramalan MA, Gezawa ID, Puepet FH, Uloko AT, Borodo MM, Sada KB. Prevalence and Risk Factors for Diabetes Mellitus in Nigeria: A Systematic Review and Meta-Analysis. Diabetes Ther. 2018; 9(3):1307–1316.
Akwiwu EC, Edem MS, Akpotuzor JO, Isong IK, Okafor AO, Okhhormhe ZA. Glycemic control and associated platelet indices among apparently healthy caregivers in Southern Nigeria. NZ. J. Med. Lab. Sci. 2020; 74:87-90.
Sabir AA, Balarabe S, Sani AA, Isezuo SA, Bello KS, Jimoh AO, Iwuala SO. Prevalence of diabetes mellitus and its risk factors among the sub-urban population of northwest Nigeria. Sahel Med J. 2017; 20:168-172.
World Health Organization. Classification of diabetes.Geneva: World Health Organization 2019. Available from: https://www.who.int accessed 14th April, 2021.
Bahijri SM, Jambi HA, al-Raddadi RM, Ferns G, Tuomileto T. The prevalence of diabetes and prediabetes in the adult population of Jeddah, Saudi Arabia – a community-based survey. PLoS One 2016; 11(4): e0152559.
Bellatorre A, Jackson SH, Choi K. Development of the diabetes typology model for discerning Type 2 diabetes mellitus with national survey data. PloS One 2017; 12: e0173103.
American diabetes Association. Diabetes: New recommendations challenge decades-old guidelines. 2018 Healthline.
Avilés-Santa ML, Schneiderman N, Savage PJ Kaplan RC, Teng Y, Perez CM, Suarez EL, Cai J, Giachello AL, Talavera GA, Cowie CC. Identifying probable diabetes mellitusamong Hispanics/Latinos from four U.S. cities: findings from the Hispanic community health study/ study of Latinos.
Endocr Pract. 2016; 22:1151–1160.
Edem MS, Akwiwu EC, Akpotuzor JO. Endothelial cell markers in diabetes and prevalence of uncontrolled type 2 Diabetes Mellitus in Southern Nigeria. NZ. J. Med. Lab. Sci.2022; 76: (1):15-17.
Edem MS, Akwiwu EC, Akpotuzor JO, Asemota EA, Isong IK. Glycated Haemoglobin, Fasting Plasma Glucose, Plasminogen Activator Inhibitor Type-1 and Soluble Thrombomodulin Levels in Patients with Type 2 Diabetes Mellitus. Niger. J. Physiol. Sci. 2021; 36 (2):159–164.
Pernow J, Kiss A, Tratsiakovich Y, Climent B. Tissuespecific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus. Br. J. Pharmacol. 2015; 172:4684–4698.
Lau YS, Ling WC, Murugan D, Mustafa MR. Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes. J. Cardiovasc. Pharmacol. 2015; 65:522–531.
Chudy P, Kotuhëová D, Stäsko J, Kubisz P. The relationship among TAFI, t-PA, PAI-1 and F1+2 in type 2 diabetic patients with normoalbuminuria and microalbuminuria.Blood 2011; 22:493-498.
Elsalakawy WA, Farweez BA, Sallam MT, Hamza MA. High levels of soluble thrombomodulin maybe a marker of arterial disease and peripheral ischemia in Egyptian patients with diabetes mellitus. Egypt J. Haematol. 2014; 39:52-57.
Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta A, Singh S. Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology; 2011; 16 (2):86-89.
Shah B, Sha D, Xie D, Mohler ER, Berger JS. The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume. The national health and nutrition examination survey, 1999-2004. Diabetes care, 2012; 35 (5):1074-1078.
Chen X, Fang L, Lin H, Shen P, Zhang T, Li H, Li X, Yu M, Xu C, Zhang J, Lu F, Du X, Hu R, Zhong J. The relationship between Type 2 Diabetes and Platelet Indicators. Iran J Public Health. 2017;46(9):1211-1216.
Sell DR, Monnier VM. Molecular basis of arterial stiffening: role of glycation – a mini-review. Gerontology 2012; 58:227-237.
Kaur R, Kaur M, Singh J. Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies. Cardiovasc. Diabetol. 2018; 17:121.
Sobol AB, Watala C. The role of platelets in diabetes-related vascular complications. Diabetes Res Clin Pract. 2000; 50:1-16.
Winocour PD. The role of platelets in the pathogenesis of diabetic vascular disease. In: Complications of Diabetes Mellitus. Molecular and Cellular Biology of Diabetes Mellitus, Vol. III. Draznin B, Melmed S, LeRoith D. (eds) Alan R Liss Inc., New York: 1989. pp 37-47.
Brakemier S, Eichler J, Knorr A, Fassheber T, Kohler R, Hoyer J. Modulation of Ca2+ activated K+ channel in renal artery endothelium in situ by nitric oxide and reactive oxygen species. Kidney Int. 2016; 64:199-207.
Carrizzo A, Izzo C, Oliveti M, Alfano A, Virtuoso N, Capunzo M, Di Pietro P, Calabrese M, De Simone E, Sciarretta S, Frati G, Migliarino S, Damato A, Ambrosio M, De Caro F, Vecchione C. The main determinants of diabetes mellitus vascular complications: Endothelial dysfunction and
platelet hyper aggregation. Int J Mol Sci. 2018; 19(10):2968.
Dogné S, Flamion B, Caron N. Endothelial glycocalyx as a shield against diabetic vascular complications: Involvement of Hyaluronan and Hyaluronidases. Arterioscler Thromb Vasc Biol. 2018; 38:1427–1439.
Favero G, Paganelli C, Buffoli B, Rodella LF, Rezzani R. Endothelium and Its Alterations in Cardiovascular Diseases: Life Style Intervention. BioMed Research Intl. 2014; 801896.
Schiattarella GG, Carrizzo A, Ilardi F, Damato A, Ambrosio M, Madonna M, Trimarco V, Marino M, De Angelis E, Settembrini S, Perrino C, Trimarco B, Esposito G, Vecchione C. Rac1 Modulates Endothelial Function and Platelet aggregation in diabetes mellitus. J Am Heart Assoc. 2018;
Rusdiana RS, Widjaja S, Savira M, Amelia R, Rusmalawati R. Assessment of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor in Type 2 Diabetes Mellitus Patients in North Sumatera, Indonesia. Tropical Journal of Natural Product Research 2021; 5(11):1919-1921.