Isolation of Lignans from The Stem Bark of Willughbeia coriacea and Their Cytotoxic Activity http://.www.doi.org/10.26538/tjnpr/v7i2.14

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Published: Feb 28, 2023
Keywords:
HeLa cells, alyterinate A, ( )-pinoresinol, lignan, Willughbeia coriacea

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Andre Harsono
Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia
Abror Rahman
Rizqidhana J. Putri
Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia
Tjitjik S. Tjahjandarie
Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia
Ratih D. Saputri
Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya 60231, Indonesia
Norizan Ahmat
Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Mulyadi Tanjung
Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia

Abstract

Willughbeia coricea Wall is a herbal medicine to treat diarrhea in Dayak People, Kalimantan, Indonesia. This study aims to determine the structure of the lignans and their anticancer activity against cervical cancer cells (HeLa). Two lignan derivatives, (+)-pinoresinol (1) and alyterinate A (2), were isolated from the roots of the W. coricea Wall. The structures of 1 and 2 were determined based on UV, IR, HRESIMS, 1D (1H and 13C), and 2D NMR (HMQC and HMBC) spectroscopic analysis. Compounds 1-2 showed moderate activity against HeLa cells with an IC50 value of 10.1 and 12.5 μM, respectively.

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How to Cite
Harsono, A., Rahman, A., Putri, R. J., Tjahjandarie, T. S., Saputri, R. D., Ahmat, N., & Tanjung, M. (2023). Isolation of Lignans from The Stem Bark of Willughbeia coriacea and Their Cytotoxic Activity: http://.www.doi.org/10.26538/tjnpr/v7i2.14. Tropical Journal of Natural Product Research (TJNPR), 7(2), 2394-2396. https://tjnpr.org/index.php/home/article/view/1654
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Vol. 7 No. 2 (2023): Tropical Journal of Natural Product Research (TJNPR)
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Harsono, A., Rahman, A., Putri, R. J., Tjahjandarie, T. S., Saputri, R. D., Ahmat, N., & Tanjung, M. (2023). Isolation of Lignans from The Stem Bark of Willughbeia coriacea and Their Cytotoxic Activity: http://.www.doi.org/10.26538/tjnpr/v7i2.14. Tropical Journal of Natural Product Research (TJNPR), 7(2), 2394-2396. https://tjnpr.org/index.php/home/article/view/1654

References

Tanjung M, Tjahjandarie TS, Saputri RD, Harsono A, Aldin MF. A new cinnamyl acid derivate from the roots of Willughbeia coriacea Wall. Nat. Prod. Sci, 2020; 26(1):79-82.

Can MV, Tran AH, Pham DM, Dinh BQ, Le QV, Nguyen BV, Nguyen MTT, Nguyen HX, Nguyen NT, Nishijo H. Willughbeia cochinchinensis prevents scopolamine-induced deficits in memory, spatial learning, and object recognition in rodents, J. Ethnopharm, 2018; 214:99-105.

Heyne K. The useful Indonesian plants. Research and Development Agency. Ministry of Forestry. Jakarta. Indonesia. 1987; 3065.

Saputri RD, Retnowati R, Supratman U, Tjahjandarie TS, Tanjung M. Three novel quinolinone alkaloids from the leaves of Melicope denhamii. Nat. Prod. Res, 2023; 37(2):197-203.

Saputri RD, Tjahjandarie TS, Tanjung M. Two novel coumarins bearing acetophenone derivative from the leaves of Melicope quercifolia. Nat. Prod. Res, 2021; 35(8):1256-1261.

Tjahjandarie TS, Tanjung M, Saputri RD, Aldin MF, Aldin MF, Susanti RA, Wibawa RS, Halizah IN. Cytotoxicity evaluation of two new chalcones from the leaves of Flemingia macrophylla (Willd.) Merr. Phytochem. Lett,2021; 44:78-81.

Tanjung M, Juliawaty LD, Hakim EH, Syah YM. Flavonoid and stilbene derivatives from the Macaranga trichocarpa. Fitoterapia, 2018; 126:74-77.

Tjahjandarie TS, Tanjung M, Saputri RD, Nadar PB, Aldin MF, Permadi A. Flavestin K, an isoprenylated stilbene from the leaves of Macaranga recurvata Gage. Nat. Prod. Sci,2019; 25(3):244-247.

Tanjung M, Tjahjandarie TS, Mardhiyyah S, Rahman GZ, Aldin MF, Saputri RD, Ahmat N. Two new flavanones from the leaves of Flemingia lineata (L.) Aiton. Nat. Prod. Sci,2022; 28(2):58-61.

Miyazawa M, Kasahara H, Kameoka H. Biotransformation of lignans: a specific microbial oxidation of (+)-eudesmin and (+)-magnolin by Aspergillus niger. Phytochem, 1993; 34(6):1501-1507.

Wangteeraprasert R, Lipipun V, Gunaratnam M, Neidle S, Gibbons S, Likhitwitayawuid K. Bioactive compounds from Carissa spinarum. Phyther Res, 2012; 26(10):1496-1499.

Sriphana U, Thongsri Y, Ardwichai, P, Poopasit K, Prariyachatigul C, Simasathiansophon S, Yenjai C. New lignan esters from Alyxia schlechteri and antifungal activity against Pythium insidiosum, Fitoterapia, 2013; 91: 39-43.

Tanjung M, Tjahjandarie TS, Saputri RD, Kurnia BD, Rachman MF, Syah YM. Acronyculatin P, a new isoprenylated acetophenone from the stem bark of Acronychia pedunculata. Nat. Prod. Sci, 2018; 24(4):284-287.

Tanjung M, Nurmalasari I, Wilujeng AK, Saputri RD,Rachmadiarti F, Tjahjandarie TS. Calotetrapterins A-C, three new pyranoxanthones and their cytotocity from the stem bark of Calophyllum tetrapterum. Nat. Prod. Res, 2021; 35(3):407-412.