Chronic Administration of Hydroalcoholic Extract of Newbouldia laevis Leaves Induces Electrolyte Imbalance and Dyslipidemia in Wistar Rats http://www.doi.org/10.26538/tjnpr/v7i1.26
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Abstract
Newbouldia laevis is a medicinal plant widely used for various ailments in Africa,but little is known about its effect on serum electrolytes and lipids after chronic use. In this study, effects of prolonged administration of hydroalcoholic extract of Newbouldia laevis leaves (CEE) on serum electrolytes and lipids were investigated in rats. Wistar rats were treated daily with CEE (150 – 600 mg/kg b.w) for 120 days. Thereafter they were sacrificed and serum lipids and electrolytes were analyzed. Data obtained were analyzed by one-way analysis of variance (ANOVA) and Tukey’s post hoc test, and p<0.05 was considered significant. The results showed that 600 mg/kg b.w of CEE caused a significant (p<0.05) decrease in serum levels of sodium and chloride ions. There was significant (p<0.05) increase in serum levels of potassium and bicarbonate ions. CEE (300 and 600 mg/kg b.w.) caused significant increase (p<0.05) in the serum levels of triglycerides, total cholesterol, low density lipoprotein cholesterol, and very low density lipoprotein cholesterol in the CEE-treated rats compared to the control. There was also a significant reduction in the level of high density lipoprotein cholesterol (HDL-c). Levels of these parameters were not significantly different (p>0.05) from the control following the 28-day withdrawal of CEE. From our findings, we conclude that prolonged use of extract of Newbouldia laevis leaves could result in electrolyte imbalance and dyslipidemia. Although withdrawal of the extract after long term use could ameliorate its adverse effects, the plant should be used with caution.
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