Antidiabetic Potentials of Ethanol Extract of Timonius flavescens (Jacq.) Baker Leaf http://www.doi.org/10.26538/tjnpr/v7i1.5
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Abstract
Diabetes Mellitus (DM) is a chronic disease caused by heredity or deficiency in insulin secretion. This disease has occupied the second position as an epidemic in Indonesia. The World Health Organization (WHO) states that nearly 70% of diabetic patients use plants as the main source of antidiabetic agents. One of the plants used by the community for a long time to lower blood sugar is Timonius flavescens (family Rubiaceae). This study aims to determine the content of antidiabetic active compounds in the ethanol extract of T. flavescens leaves by using mass
spectrometry gas chromatography (GC-MS). The results of GC-MS showed that there were more than 40 compounds, then 10 of them had the highest value detected as having antidiabetic agent properties. These compounds include (3β)- stigmast-5-en-3-ol, 3β.-(acetyloxy)-15.-hydroxy- 5..-cholesta-8(14),9(11)-dien-7-one, alpha-tocopherol, hexade-canoic acid, nonanoic acid, phytol, 2,3-dihydrobenzofuran, heptanoic acid, neophytadiene, and campesterol which have been shown to have antidiabetic properties. The results of this study are expected to provide critical
information for researchers and the public regarding the use of T. flavescens leaves as medicine.
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