Anti-Hyperglycemic and Anti-Inflammatory Activities of Moringa oleifera Lam Leaves Extract doi.org/10.26538/tjnpr/v6i6.10
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Abstract
Moringa oleifera has been known for its nutritional content and health benefit. As a medicinal plant, it has been used to control and treat diabetes with minimal or no side effects. Hence, this study investigated the anti-hyperglycemic and anti-inflammatory activity of Moringa leaf extract (MLE). Extracts were obtained by maceration with 1 L of 70% ethanol, ethyl acetate, and n hexane. Anti-hyperglycemic activity of MLE was evaluated through alpha-amylase and alpha glucosidase inhibition, while anti-inflammatory activity was analyzed by protein denaturation method. The results showed that ethyl acetate extract of Moringa leaves had the strongest inhibition against alpha-amylase (IC50 = 0.243 g/mL) and alpha-glucosidase (IC50 = 0.470 g/mL). Meanwhile, the greatest anti-inflammatory activity (IC50 = 0.217 g/mL) was shown by n-hexane extract of Moringa leaves. In conclusion, Moringa leaves have anti-hyperglycemic and anti-inflammatory activities.
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