In Vivo Evaluation of Antidiabetic Effects of Some Polyherbal Formulations in Alloxan-Induced Diabetic Wistar Rats doi.org/10.26538/tjnpr/v6i5.26
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Abstract
Diabetes is one of the most prevalent issues confronting public health in the 21st century. As humans become more interested in using plant-based formulations for the treatment of diabetes, the market for Ayurvedic, nutraceutical, and polyherbal formulations is rapidly expanding. In this study, the antidiabetic effects of polyherbal formulations of tomato, garlic, and carrot in Wistar rats are presented. The botanicals were taxonomically verified and their equal weights were shed-dried, crushed to a fine-powdered form and formulated in uniform ratios. A nutrient composition was assayed by a standard guideline. Effect of the formulations on body weight, fasting blood glucose, lipid profile, serum biochemistry, and oxidative stress were subsequently evaluated. At 150 mg/kg dose each, the formulations significantly (p ˂ 0.05) improved the body weight and reduced the fasting blood glucose of the diabetic rats. There was a significant (p ˂ 0.05) reduction in serum glucose, increase in haemoglobin level, restoration of the lipid profile and oxidative stress markers of the treated diabetic rats in comparison to the untreated rats. These findings have led us to the conclusion that employing safe combinations of the formulation of these botanicals for the production of antidiabetic nutraceuticals may be beneficial.
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