Anti-Diabetic Potential of Silver (AgNPs) and Gold (AuNPs) Nanoparticles Synthesized Using an Aqueous Extract of Opuntia ficus indica Cladodes in Wistar Rats doi.org/10.26538/tjnpr/v6i7.19

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Published: Jul 1, 2022
Keywords:
Diabetes mellitus,, Streptozotocin,, Opuntia ficus indica,, Albino rats,, Nanoparticles.

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Jelilat B. Ibikunle
Department of Pure and Applied Biology, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Nigeria
Elijah A. Adebayo
Department of Pure and Applied Biology, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Nigeria
Abel M. Oke
Microbiology and Biotechnology Laboratory, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso Nigeria
Jelili A. Badmus
Department of Biochemistry, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Nigeria
Taofeek A. Yekeen
Department of Pure and Applied Biology, Ladoke Akintola University of Technology, PMB 4000, Ogbomoso, Nigeria
David B. Kehinde
DaveJosh Global Resource Research Laboratory, Ogbomoso, Oyo State, Nigeria

Abstract

Diabetes mellitus (DM) disease has become an increasingly important public health concern, due to its global occurrence and consequences. The study evaluated the anti-diabetic potential of silver (AgNPs) and gold (AuNPs) nanoparticles synthesized using an aqueous extract of Opuntia ficus indica (OFI) cladodes. The antidiabetic potential of OFI-extract, OFI-AgNPs, and OFI- AuNPs were investigated using sixty-three male Wistar rats consisting of seven (7) rats per group. Diabetes mellitus was induced by a single intraperitoneal injection of Streptozotocin (65 mg/kg b.w.) in groups DT5-DT9, while groups DT1-DT4 served as non-diabetic control groups. Glibenclamide (0.6 mg/kg b.w.) was used as a standard drug for twenty-eight days of treatment. OFI-AgNPs and OFI extract increased the body weight significantly (P≤0.05) in diabetic-treated rats and decreased the fasting blood glucose compared to DT5. The malondialdehyde levels of the liver and kidney (DT6 & DT8) were decreased compared with DT5. The activities of the enzymes were enhanced significantly (P<0.05) in diabetic rats treated with OFI-AgNPs and OFI-extract (DT6 & DT8) in comparison with DT5.,This finding demonstrated that OFI-AgNPs and OFI-extract protected the animals from diabetic complications associated with REDOX imbalances. Results showed that O. ficus indica can synthesize nanoparticles with potential as an anti-diabetic agent.

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B. Ibikunle, J., A. Adebayo, E., M. Oke, A., A. Badmus, J., A. Yekeen, T., & B. Kehinde, D. (2022). Anti-Diabetic Potential of Silver (AgNPs) and Gold (AuNPs) Nanoparticles Synthesized Using an Aqueous Extract of Opuntia ficus indica Cladodes in Wistar Rats: doi.org/10.26538/tjnpr/v6i7.19. Tropical Journal of Natural Product Research (TJNPR), 6(7), 1152-1158. https://tjnpr.org/index.php/home/article/view/1442
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Vol. 6 No. 7 (2022): Tropical Journal of Natural Product Research
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Articles
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

B. Ibikunle, J., A. Adebayo, E., M. Oke, A., A. Badmus, J., A. Yekeen, T., & B. Kehinde, D. (2022). Anti-Diabetic Potential of Silver (AgNPs) and Gold (AuNPs) Nanoparticles Synthesized Using an Aqueous Extract of Opuntia ficus indica Cladodes in Wistar Rats: doi.org/10.26538/tjnpr/v6i7.19. Tropical Journal of Natural Product Research (TJNPR), 6(7), 1152-1158. https://tjnpr.org/index.php/home/article/view/1442

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