Modulation of the Indices of Psychosis in Post-Convulsive Status Epilepticus Model: The Role of Proanthocyanidin-Rich Fraction doi.org/10.26538/tjnpr/v6i7.18
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Abstract
Vitis vinifera seed contains high content of flavonoids particularly, proanthocyanidins. Experimental studies have demonstrated the anticonvulsant potency of Proanthocyanidins-Rich Fraction (PRF). However, this study was designed to evaluate the psychotropic activities of PRF in the post-convulsive status epilepticus (CSE). Six groups of juvenile rats were kindled for the seizure; 24 hours later, the survived rats were post-treated intraperitoneally with propylene glycol (PG), 0.1 or with graded doses of PRF (30 mg/kg, 20 mg/kg, or 10 mg/kg body weight [BW]) or diazepam (DZP) (5 mg/kg BW) for a period of one week. Three weeks after the last treatment, both the control and post-convulsed rats were examined for the markers of depression, anxiety, and muricidal actions. they were kept untreated but with access to feed and water for 21 days. There was a significant increase in the markers of anxiety-like behavior, locomotor activities, and depression-related behavior in the post-CSE rats compared with the control. The post-CSE rats exhibited impairment in societal interaction, evidenced by muricidal actions. Additionally, there was a significant increase in depression-related behavior, especially in the anhedonia test. However, all these aberrations were attenuated following PRF treatment, a result similar to what is obtained in the diazepam treatment group.Conclusively, proanthocyanidins-rich-fraction from Viti's vinifera seed attenuates the markers of psychosis following CSE in juvenile Wistar rats.
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