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Padina australis Hauck and Turbinaria ornata (Turner) J. Agardh are two of the most common macroalgae species encountered in the Kora-kora beach coastline area. These species produced active compounds as a result of extreme environmental conditions, which could be useful in medicine. In macroalgae, these naturally occurring active substances that may have neuroprotective effects are widely distributed. This study was aimed at identifying the active antioxidant compounds with neuroprotective potential in the macroalgae collected from the Kora-kora coastal area. Padina australis and Turbinaria ornate were collected, prepared, and extracted with 96% ethanol. The antioxidant activity of the macroalgae extracts was determined using the DPPH (1,1-diphenyl-2-picrylhydrazil) technique. More so, phytochemical screening of the extracts was performed. The results indicated that the two macroalgae have high antioxidant activity. Padina australis and Turbinaria ornata had IC50 values of 16.63 and 43.22 ppm, respectively. The phytochemical analysis of these two macroalgae revealed the presence of secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, steroids, triterpenoids, and phenolics. The findings of this study suggest that both macroalgae may have neuroprotective properties.
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