Identification of Active Antioxidant Compounds with Neuro-protective Effects in Kora-kora Coastal Macro-algae

http://www.doi.org/10.26538/tjnpr/v6i12.21

Authors

  • Finny Warouw Medical Faculty, Sam Ratulangi University, Jl. Kampus Unsrat Bahu, Manado 95115, North Sulawesi, Indonesia
  • Christi Mambo Medical Faculty, Sam Ratulangi University, Jl. Kampus Unsrat Bahu, Manado 95115, North Sulawesi, Indonesia
  • Junita M. Pertiwi Medical Faculty, Sam Ratulangi University, Jl. Kampus Unsrat Bahu, Manado 95115, North Sulawesi, Indonesia
  • Veibe Warouw Faculty of Fisheries and Marine Science, Sam Ratulangi University, Jl. Kampus Unsrat Bahu, Manado 95115, North Sulawesi, Indonesia
  • Robert A. Bara Faculty of Fisheries and Marine Science, Sam Ratulangi University, Jl. Kampus Unsrat Bahu, Manado 95115, North Sulawesi, Indonesia

Keywords:

Turbinaria ornate, Padina australis, Neuro-protective properties, Antioxidant

Abstract

Padina australis Hauck and Turbinaria ornata (Turner) J. Agardh are two of the most common macroalgae species encountered in the Kora-kora beach coastline area. These species produced active compounds as a result of extreme environmental conditions, which could be useful in medicine. In macroalgae, these naturally occurring active substances that may have neuroprotective effects are widely distributed. This study was aimed at identifying the active antioxidant compounds with neuroprotective potential in the macroalgae collected from the Kora-kora coastal area. Padina australis and Turbinaria ornate were collected, prepared, and extracted with 96% ethanol. The antioxidant activity of the macroalgae extracts was determined using the DPPH (1,1-diphenyl-2-picrylhydrazil) technique. More so, phytochemical screening of the extracts was performed. The results indicated that the two macroalgae have high antioxidant activity. Padina australis and Turbinaria ornata had IC50 values of 16.63 and 43.22 ppm, respectively. The phytochemical analysis of these two macroalgae revealed the presence of secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, steroids, triterpenoids, and phenolics. The findings of this study suggest that both macroalgae may have neuroprotective properties. 

References

Dorhoi E, Michiu D, Pop C, Rotar A, Tofana M, Pop O, Socaci A, Farcas A. Macroalgae : A sustainable source of chemical compounds with biological activities. Nutr. 2020; 12(10):3085- 3095.

Ganesan A, Tiwari U, Rajauria G. Seaweed nutraceuticals and their therapeutic role in disease prevention. Food Sci Hum. 2019; 8(3):252–263.

Olasehinde T, Olaniran A, Okoh A. Macroalgae as a valuable source of naturally occurring bioactive compounds for the treatment of Alzheimer’s disease. Marine Drugs. 2019; 17(11):1- 18.

Hanan MA, Dash R, Haque N, Sohaq AM, Rahman A, Ferreres F, Andrade P. Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances. Marine Drugs. 2020; 18(7):2-50.

Syad A, Rajamohamed B, Shunmugaiah P, Kasi PD. Neuroprotective effect of the marine macroalga Gelidiella Acerosa : identification of active compounds through bioactivityguided fractionation. Pharm Biol. 2016; 54(10):2073–2081.

Munteanu I and Apetrei C. Analytical Methods used in determining antioxidant activity: a review. Int J Mol Sci. 2021; 22(7):1-30.

Shaikh JR and Patil MK. Qualitative tests for preliminary phytochemical screening: an overview. Int J Chem Stud. 2020; 8(2):603-608.

Kepel R, Lumingas L, Watung P, Mantiri D. Community structure of seaweeds along the intertidal zone of mantehage islands, north Sulawesi, Indonesia. AACL Bioflux. 2019; 12(1):87-101.

Wijayanti D, Giftania W, Oki P. Phytochemical screening of secondary metabolite Padina australis from puteran island madura. J Pharm. 2020; 2(2):60-69.

Handayani T. Knowing macroalgae Turbinaria and their usages. OSEANA. 2018; 43(4):1-10.

Sianipar A, Satriawan N, Sumartono J, Kambira P. Assessment of antioxidant activity of sumbawa macroalgae in relation to their bioactive compounds and pharmacological effects. Jurnal Riset Kesehatan Nasional. 2022; 6(2):151–157.

Kustiyah E, Saing B, Afriyanti A, Joyosemito S. Protein Characterization of Brown and Red Algae from Pari Island waters as an antioxidant substance. J Rekayasa Hijau. 2018; 2(3):247-253.

Miyashita K, Beppu F, Hosokawa M, Liu X, Wang S. Nutraceutical charateristics of brown seaweed carotenoid fucoxanthin. Archieves of Biochemistry and Biophysics. 2020; 686(108364):1-10.

Alghazwi M, Kan YQ, Zhang W, Gai WP, Garson JM, Smid S. Neuroprotective activities of natural products from marine macroalgae during 1999–2015. J Appl Phycol. 2016; 28(6):3599–3616.

Shaikh JR and Patil MK. Qualitative tests for preliminary phytochemical screening: an overview. Int. J. Chem. Stud. 2020; 8(2):603-608.

Sahnouni F, Debib A, Saim S, Bouhadi D, Menadi S. Phytochemical Content, Antioxidant and Antibacterial Activities of Three Red Macroalgae from Algerian West Coast. Trop J Nat Prod Res. 2021; 5(2):336–341.

Abid KY and Tawffiq ZS. Comparative study, phytochemical screening and antioxidant activities of three types of apple seeds extracts. Trop J Nat Prod Res. 2022; 6(9):1401-1404.

Downloads

Published

2022-12-30

How to Cite

Warouw, F., Mambo, C., Pertiwi, J. M., Warouw, V., & Bara, R. A. (2022). Identification of Active Antioxidant Compounds with Neuro-protective Effects in Kora-kora Coastal Macro-algae: http://www.doi.org/10.26538/tjnpr/v6i12.21. Tropical Journal of Natural Product Research (TJNPR), 6(12), 2025–2028. Retrieved from https://tjnpr.org/index.php/home/article/view/1420