Antihypertensive and Cardioprotective Effects of Salvia officinalis (Sage) Leaf in NGNitro-L-Arginine Methyl Ester (L-NAME) Induced-Hypertensive Wistar Rats . http://www.doi.org/10.26538/tjnpr/v6i12.25
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Abstract
Salvia officinalis (Common Sage) is a medicinal plant, used for the treatment of various disorders. The aim of this study was to evaluate the antihypertensive and cardioprotective effects of Nigerian grown Sage leaf extract in L-NAME induced hypertensive rats. Twenty- four male Wistar rats divided into four groups were used for the study. Group A served as control, while hypertension was induced in groups B-D by the administration of 40 mg/kg of L-NAME orally. Group A (Control), Group B; L-NAME (40 mg/kg/day), Group C; L-NAME (40 g/kg/day) plus Sage plant leaf extract (500 mg/kg/day) and Group D; L- arginine (100 mg/kg/day) plus LNAME (40 mg/kg/day). They were fed with feed and water ad-libitum for 28 days. Blood pressure was measured by tail-cuff weekly. On 29th day, serum was collected for the determination of Lactate dehydrogenase (LDH), creatinine phosphokinase-MB isoenzyme (CKMB), aspartate transaminase (AST), alanine transaminase (ALT), total cholesterol (Tchol) and triglycerides (TG), and were measured in an AS-120 Auto-Analyzer (E.LabBST, China: BA- 88A). Group C and D resulted to decrease in the systolic blood pressure in Weeks 3 and 4 at a
significant (p < 0.05) level compared to Group B. There was significant (p < 0.05) reduction in haemodynamic parameters in groups B & C in comparison with group A. There was significant (p < 0.05) decrease in the levels of CK-MB, LDH, AST, ALT, Tchol and TG in groups C & D compared with group B. Administration of Sage leaf extract with L-NAME possesses antihypertensive and cardioprotective activity in L-NAME induced hypertension in rats.
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