Plectranthus scutellarioides Leaf Extract Protective Effects Against Isoniazid and  Rifampicin-Induced Hepatotoxicity in Wistar Rats: http://www.doi.org/10.26538/tjnpr/v6i12.6

Lusi P. Dwita; Ni Putu E. Hikmawanti; Juhairoh Husniah; Muhammad Hazraj; Siti N. Bela; Eva Aryanti

Authors

Lusi P. Dwita Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof DR. HAMKA, East Jakarta, DKI Jakarta, 13460, Indonesia
Ni Putu E. Hikmawanti Department of Pharmaceutical Biology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof DR. HAMKA, East Jakarta, DKI Jakarta, 13460, Indonesia
Juhairoh Husniah Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof DR. HAMKA, East Jakarta, DKI Jakarta, 13460, Indonesia
Muhammad Hazraj Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof DR. HAMKA, East Jakarta, DKI Jakarta, 13460, Indonesia
Siti N. Bela Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof DR. HAMKA, East Jakarta, DKI Jakarta, 13460, Indonesia
Eva Aryanti Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof DR. HAMKA, East Jakarta, DKI Jakarta, 13460, Indonesia

Keywords:

Plectranthus scutellarioides, Hepatoprotection, Liver injury, Lamiaceae, Flavonoids, Antioxidant

Abstract

Plectranthus scutellarioides has been studied to have antioxidant and anti-inflammatory activity which shows potential with hepatoprotection effect. This study determined the hepatoprotective activity of ethanol extract of P. scutellarioides leaves. The rats were divided into five groups: PSE (Plectranthus scutellarioisdes leaves extract) 150, 300, and 600 mg/kg, negative control, and positive control (Silymarin). All groups were given the test substances concurrently with isoniazid and rifampicin (50 mg/kg) p.o every day for 28 days. The results showed that the PSE could prevent liver damage as indicated by lower levels of total bilirubin, direct bilirubin,albumin, AST, and ALT than negative controls (p<0.005). Histological observations of the liver confirmed these results, and this dose-dependent hepatoprotective activity was in line with the lipid peroxidation inhibition. P. scutellarioides extract at a dose of 600 mg/kg showed the best activity, comparable (p> 0.05) to Silymarin. The data suggest that the co-administration of P. scutellarioides leaf extract with isoniazid and rifampicin could prevent the liver injury caused by these drugs.

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