Effects of Stelechocarpus burahol [Blume] Leaf Ethanol Extract Ointment on Burns Healing

http://www.doi.org/10.26538/tjnpr/v6i9.16

Authors

  • Vera Ladeska Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. Dr. Hamka, Delima II/IV Klender, Jakarta 13460, Indonesia
  • Lusi P. Dwita Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. Dr. Hamka, Delima II/IV Klender, Jakarta 13460, Indonesia
  • Fadilla Oktaviany Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. Dr. Hamka, Delima II/IV Klender, Jakarta 13460, Indonesia
  • Ovimia F. Putri Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. Dr. Hamka, Delima II/IV Klender, Jakarta 13460, Indonesia
  • Yuni Salamah Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. Dr. Hamka, Delima II/IV Klender, Jakarta 13460, Indonesia
  • Faradita Amelia Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. Dr. Hamka, Delima II/IV Klender, Jakarta 13460, Indonesia

Keywords:

Re-epithelialisation, Fibroblast, Macrophages, Stelechocarpus burahol

Abstract

Stelechocarpus burahol [Blume] Hook.f & Thomson is a plant native to Indonesia with antibacterial, antioxidant, antifungal and antiseptic properties. This study aimed to determine the action on burns healing of a 70 % ethanol extract of Stelechocarpus burahol leaf, which was formulated as an ointment. Testing was conducted by modelling burns on rats with four parameters, namely the number of macrophages, the density of fibroblasts, the rate of reepithelialisation and measurement of the decrease in the burn wound surface area. A total of 30 rats of the Sprague Dawley strain were used in this study, divided into five groups: Stelechocarpus burahol leaf extract ointment with concentrations of 3.25%, 6.5% and 13%,vaselin flavum as a negative control and silver sulfadiazine as a positive control. Observations were made on days 3, 7 and 14 histologically. The histological observations revealed a significant decrease in the number of macrophages, increased fibroblast density and reepithelialisation compared to the negative control group, and at a concentration of 13 %, the extract’s effects were comparable to those of silver sulfadiazine. It can be concluded that Stelechocarpus burahol leaf ointment extract is capable of accelerating the healing of burn wounds, with the best results obtained at a concentration of 13%. 

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Published

2022-09-01

How to Cite

Ladeska, V., Dwita, L. P., Oktaviany, F., Putri, O. F., Salamah, Y., & Amelia, F. (2022). Effects of Stelechocarpus burahol [Blume] Leaf Ethanol Extract Ointment on Burns Healing: http://www.doi.org/10.26538/tjnpr/v6i9.16. Tropical Journal of Natural Product Research (TJNPR), 6(9), 1434–1439. Retrieved from https://tjnpr.org/index.php/home/article/view/1317