Identification of Chemical Compounds in Plumbago zeylanica Linn Leaves from Indonesia
http://www.doi.org/10.26538/tjnpr/v6i9.17
Keywords:
Plumbago zeylanica, Lupeol, Leadwort, Gas chromatography, Beta-sitosterolAbstract
Plumbago zeylanica L., commonly known as leadwort or Ki Encok plant in Indonesia, has some beneficial effects on human health, such as anticancer, anti-microbial, anti-inflammatory, wound healing, and anti-diabetic. Therefore, this experimental study aims to evaluate the chloroform extracts of P. zeylanica L. leaves for the isolation of the phytoconstituents. The crushed form of the leaves from South Sumatera (6.5 g) was macerated in 65 ml of chloroform for 5 days, while a total of 80 g leaves powder from Central Java was dissolved in 800 ml of chloroform. The extracts were filtered and evaporated to dryness using a rotary evaporator. Subsequently, the identification of secondary metabolites was carried out using Gas Chromatography-Mass Spectrometry (GC-MS). In conclusion, the leaves of P. zeylanica L. contain -sitosterol, lupeol, plumbagin, phytol, and lauric acid.
References
Roy A and Bharadvaja N. A review on pharmaceutically important medical plant: Plumbago zeylanica. J Ayurvedic Herb Med. 2017; 3(4):225–228.
Beyene BB, Alem FA, Ayana MT. Determination of antioxidant and antibacterial activities of leaf extracts of Plumbago zeylanica (Amira). Cogent Chem. 2020; 6.
Ito C, Matsui T, Takano M, Wu TS, Itoigawa M. Anti-cell proliferation effect of naphthoquinone dimers isolated from Plumbago zeylanica. Nat Prod Res. 2018; 32:2127-2132.
Rajakrishnan R, Lekshmi R, Benil PB, Thomas J, AlFarhan AH, Rakesh V, Khalaf S. Phytochemical evaluation of roots of Plumbago zeylanica L. and assessment of its potential as a nephroprotective agent. Saudi J Biol Sci. 2017; 24:760-766.
Sudhakaran MV. Histo-chromatographic finger printing profiles of the root of Plumbago zeylanica Linn and quantification of marker compound, Plumbagin. Pharmacogn J. 2017; 9(6)Suppl: s77-s86.
Pradeepa V, Senthil-Nathan S, Sathish-Narayanan S, SelinRani S, Vasantha-Srinivasan P, Thanigaivel A, Ponsankar A, Edwin ES, Duraipandiyan V, Al-Dhabi NA. Potential mode of action of a novel plumbagin as a mosquito repellent against the malarial vector Anopheles stephensi, (Culicidae: Diptera). Pestic Biochem Phys. 2016; 134:84-93.
Subramaniyan V and Paramasivam V. Potential antiinflammatory activity of Plumbago zeylanica. Asian J Pharm Clin Res. 2017; 10(10):372-375.
Karimi A, Krahmer A, Herwig N, Schulz H, Hadian J, Meiners T. Variation of secondary metabolite profile of Zataria multiflora Boiss. Population linked to geographic, climatic, and edaphic factors. Front. Plant Sci. 2020; 11:969.
Wen B, Ren S, Zhang Y, Duan Y, Shen J, Zhu X, Wang Y, Ma Y, Zou Z, Fang W. Effects of geographic locations and topographical factors on secondary metabolites distribution in green tea at a regional scale. Food Control. 2020; 110:106979.
Islam MT, Ali ES, Uddin SJ, Shaw S, Islam MA, Ahmed MI, Shill MC, Karmakar UK, Yarla NS, Khan IN, Billah MM, Pieczynska MD, Zengin G, Malainer C, Nicoletti F, Gulei D, Neagoe IB, Apostolov A, Atanasov AG. Phytol: A review of biomedical activities. Food Chem Toxicol. 2018; 121:82-94.
Hariyadi DM, Isnaeni I, Sudarma S, Shandra NMK, Rosita N. Formulation of peel-off mask containing natural antibacterial: Study on ply vinyl alcohol (PVA) and virgin coconut oil (VCO) contents. Trop J Nat Prod Res. 2021; 5(3):514-518.
Nitbani FO, Jumina, Siswanta D, Solikhah EN. Isolation and antibacterial activity test of lauric acid from crude coconut oil (Cocos nucifera L.). Procedia Chemistry. 2016; 18:132-140.
Babu S and Jayaraman S. An update on -sitosterol: A potential herbal nutraceutical for diabetic management. Biomed Pharmacother. 2020; 131:110702.
Dighe S, Kuchekar B, Wankhede S. Analgesic and antiinflammatory activity of -sitosterol isolated from leaves of Oxalis corniculata. Int J Clin Pharmacol Res. 2016; 6.
Sharmila R and Sindhu G. Evaluate the antigenotoxicity and anticancer role of -sitosterol by determining oxidative DNA damage and the expression of phosphorylated mitogenactivated protein kinases’, C-fos, C-jun, and endothelial growth factor receptor. Pharmacogn Mag. 2017; 13:95-101.
Avanti C, Remanti E, Yuniarta TA, Azminah A, Yunita O, Setiawan F. Antioxidant activity of different parts of Nauclea subdita. Trop J Nat Prod Res. 2021; 5(8):1365-1370.
Dhalani J, Dubal G, Rathod C, Nariya P. Evaluation of nonpolar composition in Plumbago zeylanica leaves by gas chromatography and mass spectrometry. Folia Med. 2020; 62(2):308-313.
Hassan G, Zahra Q, Ali I, Engel N, Ali K, Bahreen G, Ahmad VU, Aziz S, Wang D. Anticancer activity of Hispidulin from Saussurea simpsoniana and Lupeol from Vincetoxicum arnottianum. Trop J Nat Prod Res. 2020;4:31-35.
Saleem M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Lett. 2019; 285:109-115.
Sundari BKR, Telapolu S, Dwarakanath BS, Thyagarajan SP. Cytotoxic and antioxidant effects in various tissue extracts of Plumbago zeylanica: Implications for anticancer potential. Pharmacogn J. 2017; 9(5):706-712.
Cao YY, Yu J, Liu TT, Yang KX, Yang LY, Chen Q, Shi F, Hao JJ, Cai Y, Wang MR, Lu WH, Zhang Y. Plumbagin inhibits the proliferation and survival of esophageal cancel cell by blocking STAT3-PLK1-AKT signaling. Cell Death Dis. 2018; 9:17.
Demasi S, Caser M, Lonati M, Cioni PL, Pistelli L, Najar B, Scariot V. Latitude and altitude influence secondary metabolite production in peripheral Alpine populations of the Mediterranean species Lavandula angustifolia Mill. Front Plant Sci. 2018; 9:983.
Karimi A, Krahmer A, Herwig N, Hadian J, Schulz H, Meiners T. Metabolomics approaches for analyzing effects of geographic and environmental factors on the variation of root essential oils of Ferula assa-foetida L. J Agric Food Chem. 2020; 68(37):9940-9952.
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