Nasal In-situ Gel of Inert Cellulose for Allergic Rhinitis
http://www.doi.org/10.26538/tjnpr/v6i9.12
Keywords:
pH-sensitive, Inert cellulose, HPMC, Allergic rhinitis, Nasal in-situ gel, Smart gelAbstract
Allergic rhinitis is a very common disease that is treated with a variety of systemic and locally applied drugs. The advantage of nasal route of avoiding the systemic side effect of drug is outweighed by the low effectiveness of the intranasal formulations due to the rapid cleaning mechanisms of the nose. This work aims to produce nasal in-situ gel using hydroxypropyl methyl cellulose (HPMC) as the active ingredient. HPMC is an inert cellulosic material that will provide a natural barrier against the allergens and will aid in treatment and preventing the allergic rhinitis. In addition, a pH sensitive polymer (Carbopol) had been added to this formula, to provide in-situ gelling of the solution upon contact with nasal mucosa. In this work, two concentrations of HPMC (namely 0.8% and 1.6%) have been studied. All the prepared formulas were characterized by different techniques. In addition, the muco-adhesiveness, the in-vivo
retention time and the safety of the selected formula were studied. Results indicated that hydroxypropyl methyl cellulose in-situ gel can be produced with very good characteristics using 1.6% HPMC with 0.9% carbopol. The in-vitro study confirmed the moderate gelling capacity with high muco-adhesiveness. This is supported by the in-vivo retention time study which is conducted on live sheep and the recorded retention time was prolonged. The histopathology study confirmed the absence of any toxic or necrotic effect on nasal tissue. To conclude, this study succeeded in formulating a new promising, comfortable and safe treatment of allergic
rhinitis.
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