Effect of Peppermint Oil on the Characteristics and Physical Stability of Nanostructured Lipid Carrier-CoQ10 doi.org/10.26538/tjnpr/v6i3.3
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Abstract
Peppermint oil (PO) is one of the essential oils used as a enhancer in nanostructured lipid carriers (NLC), which affects the characteristics and stability of NLC. This study was aimed at determining the effect of PO on the characteristics and stability of NLC-coenzyme Q10 (NLC-CoQ10). NLC containing 1% CoQ10 was added to various concentrations (0, 1, 1.5, and 2%) of PO, namely F1-F4, respectively. The characteristics (odour, shape, viscosity, pH, particle size, and polydispersity index) of F1, F2, F3, and F4 were determined. Physical stability, centrifugation, and thermal cycle tests were performed. The results showed that adding 1-2% PO caused NLC-CoQ10 to have a distinctive PO odour, a spherical shape, and viscosity values of 329.1±10.5, 307.6±27.4, 220.4±4.0, and 219.9±2.2 cps for F1, F2, F3, and F4, respectively. The pH values ranged from 6.33 to 6.36, while the particle sizes were 188.25±13.22, 197.80±14.19, 190.90±9.47, and 187.50±8.71 nm, respectively. The polydispersity index was below 0.3; and the zeta potential values ranged from –44.30 mV to –52.74 mV. F1, F2, and F3 remained stable after 30 days, whereas F4 became more fluid. The formulas performed well in a centrifuge test. The F2, F3, and F4 thermal cycle tests were all stable, but the F1 separated in the first cycle. The addition of 1, 1.5, and 2% PO did not affect the spherical morphology, the pH value, particle size, or the polydispersity index. The addition of 1.5 and 2% PO reduced viscosity, while the addition of 1 and 1.5% reduced zeta potential but increased stability.
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References
Sjerobabski-Masnec I and Situm M. Skin aging. Acta Clin Croat. 2010; 49(4):515-518.
Baumann L. Skin ageing and its treatment. J Pathol. 2007; 11(2):241-251.
Tu Y and Quan T. Oxidative stress and human skin connective tissue aging. Cosmetics. 2016; 3(3):1-12.
Wang H and Xia Q. Preparation and characterization of coenzyme Q10-loaded nanostructured lipid carriers as
delivery systems for cosmetic component. Nanotech. 2010; 3:498-501.
Ginny B, Daniel K, Doddabele M. Coenzyme Q10: Clinical update and bioavailability. J Evid-Based Compl Altern
Med. 2010; 16(2):129-137.
Emrah K, Evren G, Ozgen O. Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel
for enhanced dermal delivery. Acta Pharm. 2013;63(4):517–529.
Barcelos IPD and Haas RH. Coq10 and aging. Biology, Multidisciplinary Digital Publishing Institute. 2019; 8(2):1-22.
Erawati T, Putri D, Maharani A, Rosita N, Soeratri W. Characteristics and stability of nanostructured lipid carrier
(NLC) Aleurites moluccana seed oil (AMS oil) using various combinations of beeswax and oleum cacao. Int J Drug Deliv Technol. 2019; 9(1):94-97.
Shoviantari F, Erawati T, Soeratri W. Skin penetration of coenzyme Q10 in nanostructure lipid carriers using olive oil
and cetyl palmitate. Int J Pharm Clin Res. 2017:9(2):142-145.
Das ASHA and Ahmed AB. Natural permeation enhancer for transdermal drug delivery system and permeation
evaluation: A review. Asian J Pharm Clin Res. 2017; 10(9):5-7.
Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A, Khorasani S, Mozafari MR. Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics, Multidisciplinary Digital Publishing Institute. 2018; 10(2):1-17.
Hua S. Lipid-base nano-delivery system for skin delivery of drugs and bioactive. Front Pharmacol. 2015; 6(1):1-5.
Shah R., Eldrige D, Palombo E, Hording I. Lipid nanoparticles: Production, characterization, and stability.
Ed. 1, Melbourne, Springer Cham Heildelberg New York Dordrecht London. 2015; 59-75p.
Müller RH, Staufenbiel S, Keck CM. Lipid nanoparticles (SLN, NLC) for innovative consumer care and household products. H and PC Today. 2014; 9(2):18-25.
Tian Y, Chen L, Zhang W. Influence of ionic surfactants on the properties of nanoemulsions emulsified by nonionic surfactants Span 80 / Tween 80. J Disp Sci Technol. 2016; 37(10):1511-1517.
Witayaudom P and Klinkesorn U. Effect of surfactant concentration and solidification temperature on the characteristics and stability of nanostructured lipid carrier (NLC) prepared from rambutan (Nephelium lappaceum L.)
kernel fat. J Coll Interf Sci. 2017; 505(1):1082-1092.
Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Exipients (Sixth Edition). In: The Pharmaceutical Press and American Pharmacists Association, 6th ed., London: The Pharmaceutical Press. 2009; 155-593p.
Rezania D. Optimization of kopyor coconut (Cocos nucifera L.) virgin coconut oil emulgel formula and antibacterial activity test on Propionibacterium acnesATCC. 11827. Thesis. Faculty of Pharmacy. Airlangga University: Surabaya. 2019; 54-68p.
Ng WK, Yazan LS, Yap LH, Nor Hafiza WAG, How CW, Abdullah R. Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa). BioMed Res Int. 2015; 2015(Article ID 263131):1-10.