Antioxidant, Anti-hyperlipidemic and Cardioprotective Potentials of Diet Supplemented with Parkia biglobosa Roasted Seeds on Isoproterenol-Induced Cardiotoxicity in Wistar rats

http://www.doi.org/10.26538/tjnpr/v6i11.23

Authors

  • Adetoun E. Morakinyo Department of Biochemistry, Faculty of Science, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
  • Femi E. Omoniyi Department of Biochemistry, Faculty of Science, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
  • Samuel C. Nzekwe Department of Biochemistry, Faculty of Science, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
  • Idris O. Agbabiaka Department of Biochemistry, Faculty of Science, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
  • Paula A. Odole Department of Biochemistry, Faculty of Science, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
  • Abel K. Oyebamiji Department of Chemistry and Industrial Chemistry, Bowen University, Iwo, Osun State, Nigeria
  • Anyim Godwin Department of Biochemistry, Faculty of Science, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
  • Kafayat O. Bello-Ogunesan Department of Chemistry, University of Lagos, Lagos State, Nigeria
  • Emmanuel T. Akintayo Department of Chemistry and Industrial Chemistry, Bowen University, Iwo, Osun State, Nigeria
  • Cecillia O, Akintayo Department of Chemistry and Industrial Chemistry, Bowen University, Iwo, Osun State, Nigeria
  • Sunday A. Akintelu School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100811, China
  • Temitope A. Oyedepo Department of Biochemistry, Faculty of Science, Adeleke University, P.M.B. 250, Ede, Osun State, Nigeria.
  • Jonathan O. Babalola Department of Chemistry, University of Ibadan, Ibadan, Oyo State, Nigeria

Keywords:

Parkia biglobosa, Cardiotoxicity, Cardio-protective, Hyperlipidemic, Antioxidants

Abstract

Metabolic diseases including overweight and cardiovascular diseases have increased to epidemic proportions with cardiovascular diseases as the most common non-communicable diseases globally. In this work, the major aim is to investigate the biological potentials of roasted P. biglobosa seed in the prevention of cardiovascular diseases. Dry P. biglobosa seeds were pulverized and 100 g were extracted in 85% ethanol for 72 h and filtered. Antioxidant potential was evaluated via DPPH scavenging and ferric reducing antioxidant power (FRAP). Thereafter, 24 male Wistar rats (100-150 g) were randomised into four groups and treated as follow: Group
1 (normal saline only), Group 2 (normal saline + ISO 85 mg/kg), Group 3 (1.8 mg/kg propanolol pretreatment + ISO 85 mg/kg); and Group 4 (fed with supplemented P. biglobosa roated seeds (20%) + ISO 85 mg/kg). Twenty-four hours after induction the rats were anaesthesised using diethylether and sacrificed. Blood samples were collected into EDTA bottles by cardiac puncture. Also, based on the earlier reports of the GC-MS profiles, five constituents were selected, optimized and docked against angiotensin converting enzyme (PDB ID: 1O8A) using insilico method. Results showed presence of saponins, phenols and there was a significant decrease in triglycerides and cholesterol in the extract-treated rats when compared with the cardiotoxicity control group. Meanwhile there was no significant difference in the concentration of HDL-c across the group. The study concluded that diet supplemented with P. biglobosa
roasted seeds possessed cardioprotective activity which was mediated via lipid lowering and antioxidant mechanisms in isoproterenol challenged rats. 

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Published

2022-11-01

How to Cite

Morakinyo, A. E., Omoniyi, F. E., Nzekwe, S. C., Agbabiaka, I. O., Odole, P. A., Oyebamiji, A. K., … Babalola, J. O. (2022). Antioxidant, Anti-hyperlipidemic and Cardioprotective Potentials of Diet Supplemented with Parkia biglobosa Roasted Seeds on Isoproterenol-Induced Cardiotoxicity in Wistar rats: http://www.doi.org/10.26538/tjnpr/v6i11.23. Tropical Journal of Natural Product Research (TJNPR), 6(11), 1882–1887. Retrieved from https://tjnpr.org/index.php/home/article/view/1243